ganglioside

(redirected from Gangliosides)
Also found in: Dictionary, Medical.

ganglioside

[′gaŋ·glē·ō‚sīd]
(biochemistry)
One of a group of glycosphingolipids found in neuronal surface membranes and spleen; they contain an N-acyl fatty acid derivative of sphingosine linked to a carbohydrate (glucose or galactose); they also contain N-acetylglucosamine or N-acetylgalactosamine, and N-acetylneuraminic acid.
References in periodicals archive ?
Secondly, as discussed above, both CT and LT also bind with high affinity via their B-subunits to GM1 ganglioside receptors, which are present on most mammalian cells including not only epithelial cells, such as the "M cells" covering the Peyer's patches, but also all known antigen-presenting cells (APCs); this facilitates the uptake and presentation of the toxins to the gut mucosal immune system.
Gangliosides expresses by renal cell carcinoma cell line SK-RC-45 are involved in tumour-induced apoptosis of T cells.
(18) As the mI peak signifies glial cell activity, it has been hypothesised that accumulation of [GM.sub.2] gangliosides results in glial cell proliferation, or reactive gliosis.
Characterization and biological activity of gangliosides in buffalo milk.
What you should know is that gangliosides are made by every cell.
Other therapies evaluated were vincristine iontophoresis, acupuncture, intrathecal methylprednisolone, and subcutaneous administration of a mixture of gangliosides (Table 1).
They focused on antibodies against gangliosides -- molecular markers found on cancer cells but not on normal cells.
The majority of sialic acid in the brain is bound to gangliosides. Sialic acid is an essential component of brain gangliosides that impact cell to cell communication in the nervous system.
The lower radioactivity in the aqueous phase derived from DRM of infected cells could be attributed to gangliosides GM3 and GM1 (Figure 12(a)).
Matreya's specialty is in producing high-purity sphingosines, ceramides, sulfatides, globotriaosylceramides, gangliosides, enzyme inhibitors, tocopherols, and tocotrienols.
High incidence of antibodies to 5-hydroxytryptamine, gangliosides and phospholipids in patients with chronic fatigue and fibromyalgia syndrome and their relatives: evidence for a clinical entity of both disorders.
GM2 gangliosides occur due to the enzymatic presentation of impaired activity of hydrolase b-hexosaminidase or rarely from defects in GM2 activator protein.