ganglioside

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ganglioside

[′gaŋ·glē·ō‚sīd]
(biochemistry)
One of a group of glycosphingolipids found in neuronal surface membranes and spleen; they contain an N-acyl fatty acid derivative of sphingosine linked to a carbohydrate (glucose or galactose); they also contain N-acetylglucosamine or N-acetylgalactosamine, and N-acetylneuraminic acid.
References in periodicals archive ?
He pointed out that phospholipids and sphingolipids, including gangliosides, are essential for early brain development, and plays an important role in neural development and function.
These findings support the hypothesis that the sialic acid in human milk may contribute significantly to greater concentrations of gangliosides in the brains of breastfed infants and to the observed neurological and intellectual advantages of breastfeeding over formula feeding.
1995) Ewes' milk: changes in the contents of gangliosides and sialic acid during lactation.
The seroimmunological study of anti-glycolipid antibodies conducted by enzyme immunoassay showed the presence of immunoglobulin G antibodies against ganglioside GM1 at a titer of >1/1,000.
They have discovered that in mice missing the sugar containing lipid ganglioside GD3, neural stem cells have a dramatically impaired ability to self-renew, said Robert K.
Identification of gangliosides GD1b and GT1b as receptors for BK virus.
A CTC immunocapture was developed utilizing IgM human mAb against 3 melanoma-related gangliosides [GM3 (13), GM2 (14), and GD2 (15)] coupled to immunomagnetic beads.
Changes in serum acute phase reactants, inflammatory mediators and gangliosides in Japanese quail (Coturnix japonica) with retained yolk sac.
Several lines of evidence indicate that TeNT binding to its receptor depends on gangliosides (notably gangliosides of the 1 b series), and GPI-anchored glycoproteins (17-21).
13,14) In addition, A[beta]-tumover can be modulated, for example by glucose, insulin, or gangliosides.
Lysosomal sialidase (neuroaminidase) cleans sialic acid residues located in the last part of gangliosides, oligosaccharides and glycoproteins.
The amyloid [beta]-protein has a strong binding affinity towards gangliosides.