Gastrin


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Related to Gastrin: enterogastrone, somatostatin, secretin

gastrin

[′gas·trən]
(biochemistry)
A polypeptide hormone secreted by the pyloric mucosa which stimulates the pancreas to release pancreatic fluid and the stomach to release gastric acid.

Gastrin

 

a polypeptide hormone secreted by the mucous membrane of the pylorus of the stomach; it is secreted when the pylorus is stretched or acted on by chemical stimulants (for example, products of the decomposition of food) or impulses from the vagus nerves. Gastrin increases the secretion of gastric and pancreatic juices, as well as of bile, and alters the tone and motility of the stomach and intestines. An increase in the hydrochloric-acid content of the pylorus (when acidic gastric juice enters it) inhibits the secretion of gastrin. Two kinds of gastrin, which are very similar in structure and physiological properties, have been distinguished. Gastrin has been synthesized chemically.

References in periodicals archive ?
Expression and processing of gastrin in hepatocellular carcinoma, fibrolamellar carcinoma and cholangiocarcinoma.
This may be due to increased gastrin secretion, parietal cell hyperplasia or upregulation of proton pump activity.
Lung cancers exhibit higher expression and content of gastrin and its receptors are akin to the upregulation of gastrin biosynthesis already described for gastric cancers and colorectal cancers (1).
Foster et al., "Targeting of CCK-2 receptor-expressing tumors using a radiolabeled divalent gastrin peptide," Journal of Nuclear Medicine, vol.
Tumour Age to Biochemical test Imaging test begin(y) annually (Time interval) Parathyroid 8 Calcium, PTH None Pancreas 20 Gastrin None Gastrinoma Insulinoma 5 Fasting glucose, None Insulin Other <10 Chromogranin-A, MRI, CT or pancreatic NET PP, glucagon, VIP endoscopic US Pituitary 5 Prolactin, IGF-1 MRI (every 3 y) Adrenal 19 None unless >1cm lesion or MRI or CT symptoms Thymic and 15 None CT or MRI(1-2y) bronchial carcinoid
The possible mechanisms involved in this process include decreased pancreatic polypeptide, glucagon, cholecystokinin, gastrin and gastrointestinal hormone levels, D cell damage reduction and improved somatostatin synthesis and release.
It is important to mention that ghrelin plasma levels may be affected by other hormones, such as gastrin and leptin (27,38), and especially by age, as reported by Nouh et al.
NETs lead to increased hormone production which most commonly can result in low blood sugar if too much insulin is produced, high blood sugar if too much glucagon is produced, and gastric ulcers if too much gastrin is produced.
pylori strains have been shown to affect the secretion of several hormones, including 5-HT, ghrelin, dopamine, and gastrin, and altered levels of these hormones might be the cause of the psychological disorders of functional dyspepsia patients.
Further investigations were also positive for intrinsic factor-blocking antibodies and an elevated gastrin level consistent with a diagnosis of pernicious anemia.