Tetracyclines come under the family of antibiotics which inhibit the catalytic activity of human collagenases and gelatinases
, especially MMPs.
Degradation of basement membranes by gelatinases
that are only metalloproteinases able to degrade basement membrane collagen (type IV) may result in the formation of distant metastases.
Assessment of gelatinases
(MMP-2 and MMP-9) by gelatin zymography.
The virulence of Aeromonas is considered multifactorial, as it is practically impossible to establish a hierarchy in the classification of its virulence factors according to their part in the disease process, and the following factors have been identified as virulence indicators: hemolysins, proteases, lipases, enterotoxins, gelatinases
, elastases, among others (Rabaan, Gryllos, Tomas, & Shaw, 2001; Nam & John, 2007; Peixoto et al.
Then, we compared the amounts of both active gelatinases
measured in the CSF of MS patients and OND controls.
(MMP-2 and MMP-9) have a compact collagen binding domain called fibronectin-like domain within the catalytic domain.
Biodegradation of feather waste by extracellular keratinases and gelatinases
from Bacillus spp.
Due to structural and substrate specificity, MMPs are currently divided into seven classes: collagenases (MMP1, MMP8, MMP13, and MMP18), gelatinases
(MMP2 and MMP9), stromelysins (MMP3, MMP10), stromelysin like (MMP11 and MMP12), matrilysins (MMP7 and MMP26), membrane type (MMP14, MMP15, MMP16, MMP17, MMP24, and MMP25), and others (MMP19, MMP20, MMP21, MMP22, MMP23, MMP27, and MMP28) [18, 27, 28].
Cellular localization of gelatinases
and tissue inhibitors of metalloproteinases during follicular growth, ovulation, and early luteal formation in the rat.
Selective inhibition of SalA on gelatinases
than collagenases in vitro
MMPs are divided into subgroups, distinguished by specific structural domains: collagenases, gelatinases
, stromelysins, matrilysins, metaloelastases, and membrane type matrix metalloproteinases (MT-MMPs) (Figure 5) .
Digestive gland activity was also reduced almost completely by this inhibitor, demonstrating the presence of metal ion-dependent gelatinases
in digestive tissues.