Several polymorphic variants have been described in the APOC3 gene promoter
, affecting protein transcription and synthesis (11); among them, promoter variants at positions -455 and -482 have been studied more extensively because of their altered affinity for the nuclear transcription factors that mediate the insulin response (12).
Through the application of its core technologies, the XenoSensor Mice, implanted with human SXR, CAR or CYP3A4 gene promoter
, coupled with XenoPharm's CleanScreen high-throughput screening assays XenoPharm provides a proprietary technology platform to improve the predictive value of cell and animal-based biomedical research.
MMP7 gene promoter
sequences were obtained from peripheral blood samples from 58 consecutive patients with CRC of different stages who underwent surgery and from 111 sex- and age-matched healthy individuals (control group).
Through the application of its core technologies, the XenoSensor Mice engineered with human SXR or, CAR receptors, or the CYP3A4 gene promoter
, coupled with XenoPharm's CleanScreen high-throughput screening assays, XenoPharm provides a proprietary technology platform to improve the predictive value of cell and animal-based biomedical research.
The peer-reviewed manuscript, "Association of a single nucleotide polymorphism in the TIGR/MYOCILIN gene promoter
with the severity of primary open-angle glaucoma," published in the September 2001 issue of the journal Clinical Genetics (volume 60:3, pages 220-225), was based on a retrospective study involving 142 patients with POAG.
A novel PCR-RFLP assay for the detection of the single nucleotide polymorphism at position -1082 in the human IL-10 gene promoter
The alpha-1-antitrypsin (AAT) gene was inserted into this site under the control of a milk gene promoter
Second, the use of the telomerase gene promoter
(also cloned by Geron) is being investigated for use in viruses which selectively replicate in, and kill, cancer cells.
Molecular, haematological and clinical studies of the -101C [right arrow] T substitution of the [beta]-globin gene promoter
in 25 [beta]-thalassaemia patients and 45 heterozygotes.
The patent, number 6,054,635, covers a novel plant gene promoter
derived from raspberry fruit.
In addition, our previous findings, obtained by deletion analysis, suggest that an unknown transcriptional factor(s) binding to a negative regulatory element(s) (nucleotides -30 and +139) of the apo(a) gene promoter
may be affected by aspirin (17).
Genzyme Transgenics provided the proprietary gene promoter
, expression technology, and technical expertise necessary for initial production and will receive royalties based on net product sales.