Genetic Polymorphism


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Related to Genetic Polymorphism: Single nucleotide polymorphism

Genetic Polymorphism

 

the coexistence within a population of two or more different hereditary forms, which are in dynamic equilibrium for several or even many generations. Genetic polymorphism is most often caused either by the varying pressures and vectors (direction) of selection under different conditions (for example, at different seasons) or by the increased relative viability of heterozygotes. One type of genetic polymorphism—balanced genetic polymorphism—is characterized by a constant optimal correlation between polymorphic forms, deviation from which proves unfavorable for the species. Balanced genetic polymorphism regulates itself automatically (an optimal correlation of forms is established). The majority of genes in man and animals are in a state of balanced genetic polymorphism. Several forms of genetic polymorphism may be distinguished; analysis of these forms makes it possible to determine the effect of selection in natural populations.

REFERENCE

Timofeev-Resovskii, N. V., and Iu. M. Svirezhev. “O geneticheskom polimorfizme v populiatsiiakh.” Genetika, 1967, no. 10.
References in periodicals archive ?
Besides determination of the full nucleotide sequence of the American mink growth hormone gene, sequencing aimed at detecting genetic polymorphisms within the gene and direct genotyping.
The IL-6 genetic polymorphisms may influence the expression and function of IL-6 protein, and thus affect the susceptibility to cardiovascular diseases.
It is suggested that genetic polymorphisms in the enzymes of estrogen metabolism such as CYP1A1 and CYP1B1 (the main enzymes of monooxygenase family of cytochrome P450) may affect the pathogenesis of leiomyoma [20].
Genetic polymorphisms of Pit-1 gene have also been reported in a variety of livestock such as Portuguese sheep [6], pig [4,5], Angus cattle [19], Goat [20], Indonesian local sheep [21], and Holstein cattle [22].
Flockhart, "Clinical significance of the cytochrome P450 2C19 genetic polymorphism," Clinical Pharmacokinetics, vol.
Dietary selenium intake, aldehyde dehydrogenase-2 and X-ray repair cross-complementing 1 genetic polymorphisms, and the risk of esophageal squamous cell carcinoma.
Unpublished work from our own lab has found that individuals with heroin addiction who have the ZNF804A rs1344706 genetic polymorphism (which has been linked to psychiatric disorders) are more likely to show changes in behavior and in gray matter volume, suggesting that this polymorphism can exacerbate the effects of heroin.
Some studies have reported that the hydroxylation metabolism of S-mephenytoin showed genetic polymorphism.
The results of the trial allow us to presume that the CSN1S2 genetic polymorphism in the two Chinese breed does not affect the [[alpha].
DNA repair activity of 8-oxoguanine DNA glycosylase 1 (OGG1) in human lymphocytes is not dependent on genetic polymorphism Ser326/Cys326.
The prevalence of the genetic polymorphism of CyP1A1, CYP3A5, PON1, GSTM1, GSTT1, GSTP1 and NAT2 xenobiotic polymorphism was significantly same in pesticide exposed and control subjects.