# Center

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Related to Germinal center: lymph node, mantle zone

## center,

in politics, a party following a middle course. The term was first used in France in 1789, when the moderates of the National Assembly sat in the center of the hall. It can refer to a separate party in a political system, e.g., the Catholic Center party of imperial and Weimar Germany, or to the middle group of a party consisting of several ideological factions.

## Center

in machine building, a device used to position a work-piece or mandrel on lathes, rotary grinders, and other machine tools, as well as on checking and measurement instruments.

One end of a center has a working conical surface with a vertex angle of 60° or 90°; the other has a shank with a shallow cone used to secure the center in the headstock spindle or tailstock spindle, which is an axially adjustable sleeve. If it is necessary to bore the end face of a workpiece, an opening is provided on the dead center so that a cutting tool may protrude. Machining of hollow workpieces calls for larger-diameter centers in the shape of truncated cones that fit into a conical, chamfered hole in the workpiece. Live centers, which are set in the spindle of the machine tool, have serrations on a conical working surface to transmit motion to the workpiece. In order to prevent slippage of the workpiece at higher machine speeds, the dead center may be replaced with a live center running on roller bearings. Centers are fabricated from hardened steel.

## Center

in mathematics. (1) A point O is said to be the center of symmetry of a geometric configuration if for every point A of the configuration there is another point A′ of the configuration such that O is the midpoint of the line joining A and A′. A curve or surface that has such a center is said to be central. The circle, ellipse, and hyperbola are the simplest examples of central curves, and the sphere, ellipsoid, and hyperboloid (of one or two sheets) are the simplest examples of central surfaces. It is possible for a configuration to have infinitely many centers of symmetry; for example, the centers of symmetry of a configuration consisting of two parallel lines lie on the line equidistant from the two given lines. (See alsoSYMMETRY.)

Figure 1

(2) The center of similitude of radially related configurations is the point S at which lines joining corresponding points of the configurations intersect (Figure 1).

Figure 2

(3) If all integral curves in the neighborhood of a singular point of a differential equation are closed and enclose the singular point, that point is said to be a center (Figure 2). Centers belong to the class of singular points whose character generally is not preserved when small changes are made in the right-hand side of the equation.

## center

[′sen·tər]
(industrial engineering)
A manufacturing unit containing a number of interconnected cells.
(mathematics)
The point that is equidistant from all the points on a circle or sphere.
The point (if it exists) about which a curve (such as a circle, ellipse, or hyperbola) is symmetrical.
The point (if it exists) about which a surface (such as a sphere, ellipsoid, or hyperboloid) is symmetrical.
For a regular polygon, the center of its circumscribed circle.
The subgroup consisting of all elements that commute with all other elements in a given group.
The subring consisting of all elements a such that ax = xa for all x in a given ring.
(optics)
To adjust the components of an optical system so that their centers of curvature lie on a common optical axis. Also known as square-on.
(statistics)
For a distribution, the expected value of any random variable which has the distribution.

## center

1. The center ply in plywood.
2. The core in a laminated construction.
3. Centering.
4. The center about which an arc of a circle is drawn, equidistant from all points on the arc.

## centre

(US), center
1. Geometry
a. the midpoint of any line or figure, esp the point within a circle or sphere that is equidistant from any point on the circumference or surface
b. the point within a body through which a specified force may be considered to act, such as the centre of gravity
2. the point, axis, or pivot about which a body rotates
3. Politics
a. a political party or group favouring moderation, esp the moderate members of a legislative assembly
b. (as modifier): a Centre-Left alliance
4. Physiol any part of the central nervous system that regulates a specific function
5. a bar with a conical point upon which a workpiece or part may be turned or ground
6. a punch mark or small conical hole in a part to be drilled, which enables the point of the drill to be located accurately
a. the position of a player who jumps for the ball at the start of play
b. the player in this position
8. Archery
a. the ring around the bull's eye
b. a shot that hits this ring
References in periodicals archive ?
Although patients classified as IPAF had tissue specimens demonstrating NSIP, organizing pneumonia, interstitial lymphoid aggregates with germinal centers, or diffuse lymphoplasmacytic infiltrates, those features were also present in patients who did not have IPAF.
Gene expression profiling suggests primary central nervous system lymphomas to be derived from a late germinal center B cell.
Immune cell evolution is essential to our ability to fight off infections thats why Rodda wants to understand how germinal center organization makes it possible.
Studies have shown there are prognostic differences in DLBCLs that are germinal center derived (GC) versus non-germinal center derived (NGC).
A Primary Testicular Diffuse Large B-cell Lymphoma Belonging to the Germinal Center B-cell-like Group.
IRAK4 inhibitors are universally toxic towards ABC DLBCL tumors containing MYD88(L265) but not cell lines with wild type MYD88 or germinal center B-cell-like (GCB) DLBCL, consistent with the highly specific mechanism of action.
Secondary follicles form when primary follicles react to antigen stimulation and are characterized by a peripheral mantle zone of small mature B cells surrounding a central germinal center made up of antigen-selected centroblasts and centrocytes that segregate into polarized dark and light zones, respectively, with admixed tingible body macrophages and follicular dendritic cells (Figure 1, C).
To track germinal center (GC) T cells for prolong time periods in peripheral lymph nodes and GALT and determine if they enter the memory compartment.
Splenectomy specimen reveals bizonal/biphasic phenomenon/margination in the white pulp with small round lymphocytes in the center replacing the germinal center.
It would certainly be fascinating in retrospect to prove that, like a lot of folk medicine, there may have been a germinal center of truth in what they were doing.
In a poster entitled "Smac mimetic TL32711 and TRAIL synergistically induce apoptosis of germinal center B lymphoma cells" (Abstract # 3857), the pro-apoptotic effects of birinapant, alone and in combination with TRAIL, to activate the extrinsic apoptosis pathway in a panel of B cell lymphoma cell lines were investigated.

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