Globulins


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Related to Globulins: fibrinogen, Beta globulins, Serum globulins
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Globulins

 

a group of animal and plant proteins very widely distributed in nature. Globulins belong to the group of globular proteins. They are soluble in dilute solutions of neutral salts and dilute acids and alkalies but are insoluble in water (with the exception of myosin and several other globulins). They are precipitated in a semi saturated solution of ammonium sulfate, a saturated magnesium sulfate solution (at 30° C), or a saturated sodium sulfate solution (at 37° C). The molecular weights of globulins vary from a few thousand to a million or more. Most globulins are simple proteins, but some (particularly blood serum globulins) are bound to carbohydrates or lipids. The globulin of thyroid iron— thyroglobulin (molecular weight, 630,000)—is the only protein containing iodine. The globulins of nerve tissue—neuroglobulin and neurostromin—are compounds with nucleic acids (nucleoproteins). In relation to both alcohol and temperature, plant globulins (for example, glycinin, edestin, and legumin) are more stable than animal globulins.

Globulins enter into the composition of cytoplasm, blood plasma, and lymph (higher animals and humans), fixing their buffer capacity and the body’s properties of immunity. In addition to globulins, blood plasma contains protein albumins, and the albumin/globulin ratio has diagnostic significance. Normally it is near two, but it falls in inflammatory ailments. Gamma-globulin is used in medicine.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Thein, "Impact of polyclonal anti-thymocyte globulins on the expression of adhesion and inflammation molecules after ischemia-reperfusion injury," Transplant Immunology, vol.
Determination of Albumins, Globulins, Prolamins, and Glutelins in All Varieties of Phaseolus Beans.
(b) In the globulins fraction, peptide with antithrombotic activity that might inhibit the platelet aggregation was found.
In this study, there is decrease in serum globulin levels compared to matched controls in all three trimesters.
Globulins (g/dl)###3.080.17a###4.831.42b###2.660.15a###0.0040
RESULTS: In the present study, E.S.R, Serum total protein, Serum albumin, Serum globulin and RBC count were studied to investigate the modulation of these parameters in different phases of menstrual cycle.
T Lee, "FTIR spectra studies on the secondary structures of 7S and 11S globulins from soybean proteins using AOT reverse micellar extraction," Food Hydrocolloids, vol.
The failure of these cells to raise globulins to levels that are high enough to compensate for the reduced albumin may indicate advanced disease, where protein synthesis is reduced and/or protein catabolism has accelerated (Pisters and Brennen, 1990; Inui, 2002).
Studies conducted in the late 1960s indicated that clinical varicella was prevented in susceptible, healthy children by administration of zoster immune globulin (ZIG) (prepared from patients recovering from herpes zoster) within 72 hours of household exposure (4).
Proteins (albumin, pre albumin and thyroid binding globulin) produced by liver cells play an important role in metabolism and transport of thyroid hormones, therefore liver dysfunction is likely to disturb the transport of thyroid hormones resulting in disease.
The high heat of roasting destroys globulins, so that they do not appear in brewed coffee.
There were "few significant associations" among performance on neuropsychological test results and exposure to mercury in vaccines and immune globulins administered prenatally or up through 7 months of age, the authors reported.