was also obtained as a gift sample from CIFT.
(11) A 2-year double-blind RCT compared the effects of glucosamine hydrochloride
500 mg tid, chondroitin sulfate 400 mg tid, glucosamine plus chondroitin, celecoxib 200 mg/d, or placebo in 662 patients with knee OA.
, who after utilizing glucosamine hydrochloride
in their study--a valuable methodological aspect for the comparison of results --could not prove this version of the supplement to reduce pain after 24 weeks in knee OA patients with mild articular pain.
The GAIT trial found that patients with severe knee pain randomized to take 1,500 mg glucosamine hydrochloride
had a more than 65 percent reduction in pain, but those taking a combination of glucosamine and 800 mg of chondroitin sulfate had an almost 80 percent reduction in pain.
Each day, participants took either three 500-milligram doses of glucosamine hydrochloride
, three 400-milligram doses of chondroitin sulfate, both doses of glucosamine and chondroitin together, 200 milligrams of celecoxib (Celebrex) or a placebo.
Subjects in this study were older adults with type 2 diabetes who were given supplements of 1,500 mg of glucosamine hydrochloride
in combination with 1,200 mg of chondroitin sulfate (Cosamin DS[R]) for 90 days.
Biocare's Glucosamine Hydrochloride
(0121-433 3727) will help build up cartilage between her discs and reduce pain.
He suggests starting dogs on a supplement containing glucosamine hydrochloride
and chondroitin sulfate by 8 months of age.
Symptomatic treatment for the pain may be preferred and if canidryl is not working there are some veterinary nutritional supplements containing greenlipped muscle, glucosamine hydrochloride
and/or chondroitin sulphate that will do no harm and are worth a try but are unlikely to solve the problem.
For example, in October 2009, EFSA's panel concluded that "a cause and effect relationship has not been established between the consumption of glucosamine hydrochloride
and a reduced rate of cartilage degeneration in individuals without osteoarthritis"(Question number: EFSA-Q-2009-00412), Consequently, popular glucosamine supplements cannot make that claim on their packaging and in their promotion and advertising.
Navamedic, which focuses on the development and production of glucosamine hydrochloride
(HCl)-based drugs, is looking at around ten different projects.
Glucosamine, which is one of the most widely used products, showed mixed results, with glucosamine sulfate-the form most often tested in trials--scoring three out of five, and glucosamine hydrochloride
, which has a slightly different chemical structure, scoring one.