Glucuronic Acid


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glucuronic acid

[¦glü·kyə¦rän·ik ′as·əd]
(biochemistry)
C6H10O7 An acid resulting from oxidation of the CH2OH radical ofD-glucose to COOH; a component of many polysaccharides and certain vegetable gums. Also known as glycuronic acid.

Glucuronic Acid

 

one of the uronic acids, COH(CHOH)4COOH; it is formed in the body from glucose when the latter is oxidized by a primary alcohol group. It is optically active and dissolves readily in water. Melting point, 167°-172° C. D-glucuronic acid is widespread in the animal and vegetable worlds and is a component of acid mucopolysaccharides, some bacterial polysaccharides, triterpenoid saponins, hemicellulose, and gums. Free glucuronic acid is found in blood and urine in small quantities. Certain metabolic products, including some toxic products (phenol and cresol), as well as many medications, are discharged with the urine in the form of sister compounds of glucuronic acid (glucuronides). Conversions of glucuronic acid in all animals except the monkey and guinea pig, as well as in humans, lead to the biosynthesis of ascorbic acid. Body fluids and tissues of animals (especially the liver, kidneys, and spleen, and also malignant tumors) and bacterial and plant tissues contain the enzyme β-glucuronidase, which catalyzes the hydrolysis of β-glucuronides to free glucuronic acid and the corresponding aglycon.

G. A. SOLOV’EVA

References in periodicals archive ?
W., and Spiteller, G., 1999, "The reaction of hyaluronic acid and its monomers, glucuronic acid and N-acetylglucosamine, with reactive oxygen species," Carbohydr.
Glucose, N-acetyl glucosamine, and glucuronic acid were tested separately and together.
We believe rather that depletion of glucuronic acid by DPH most likely increased the hepatotoxicity of TMP-SMZ, resulting in acute fulminant hepatic failure.
Glucuronic acid excretion in urine, one indicator of detoxification capacity, did not differ between populations.
It contains glucuronic acid which helps the liver metabolise alcohol.
Ibuprofen has a half-life of approximately 2 hours; it is metabolized in the liver, where it is conjugated with glucuronic acid (Murphy, 1992).
The metabolites of catechin are all excreted in the form of methylated and demethylated forms of the catechin ring and/or conjugates with glucuronic acid, sulfate, and glycine.
Bilirubin, a metabolic product of hemoglobin, undergoes conjugation with glucuronic acid in hepatocytes to increase its water solubility.
Calibration was performed with standard solutions of L-arabinose, D-glucose, D-xylose, D-mannose, D-galactose, glucuronic acid, and galacturonic acids.
Comment: Chondroitin sulfate is a term used to denote a group of structurally similar polysaccharides, which are typically comprised of sulfated and unsulfated residues of glucuronic acid and N-acetylglucosamine.
The configuration was determined by comparing the retention time with acetylated thiazolidine derivative prepared in a similar manner from standard sugar (glucuronic acid tR 22.54 min).