Glycoproteins


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Glycoproteins

 

complex proteins containing carbohydrates. The molecular weight of glycoproteins ranges from tens of thousands to several million. These materials are present in almost all tissues and fluids of animals, including humans, in plant tissue, and in microorganisms. The glycoproteins include mucins (present in the secretions of all mucous glands, saliva, gastric juice, and cerebrospinal and seminal fluids) and mucoids (present in supportive tissue— bones, cartilage, ligaments—in the vitreous body of the eye, and in egg white). Glycoproteins include many of the blood plasma proteins (ceruloplasmin, orosomucoid, transferrin, and prothrombin), blood group components, immunoglobulins, some enzymes (pancreatic ribonuclease B, taka-amylase), and hormones (thyrotropin and the follicle-stimulating hormone). The hydrocarbon content of glycoproteins ranges from fractions of 1 percent to 80 percent. Their polysaccharide part may contain glucosamine, galac-tosamine, galactose, mannose, and other carbohydrates. According to the amino acid content, the known glycoproteins may be divided into two groups: (1) those containing the usual assortment of amino acids and small amounts of carbohydrates (3 to 40 percent) and (2) those containing a specific assortment of amino acids with predominant amounts of serine and threonine and a high carbohydrate content (60 to 80 percent).

REFERENCE

Khimiia uglevodov. Moscow, 1967.

G. A. SOLOV’EVA

References in periodicals archive ?
M2 PRESSWIRE-August 30, 2019-: Creative Biolabs Announces Custom Glycoprotein Synthesis and Glycoprotein Detections Services
Use of bovine pregnancy-associated glycoproteins to predict late embryonic mortality in postpartum Nelore beef cows.
(3) Some affect the morphological shape and integrity of the RBC membrane, including Diego (carried by Band 3), Rh-associated glycoprotein (RhAG), Rh, Gerbich (carried by glycophorins C and D), XK protein (carries Kx antigen), and Duffy.
Without a readily available method to purify the mutagenized biosimilar rAb, we used in-gel based analysis of the glycoproteins. The ingel based method was first proven to be effective when compared with in-solution based method in the analyses performed using the reference rAb sample.
We established that methanolysis of glycoproteins, followed by monosaccharide analysis e.g., by GLC of suitable derivatives is adequate for establishing the identity of the constituting monosaccharides.
We initially identified published studies that investigated the association of polymorphisms of platelet membrane glycoproteins (HPA-2a/b, Gp VIT13254C, and GP Ib[alpha] VNTR) with a risk of CHD by searching the Embase, Cochrane Library, PubMed, and CBM databases from their inception through December 31, 2016.
Flow cytometry based chronologic analysis of surface glycoproteins of resting and stimulated platelets in normal individuals.
• The kit facilitates O-glycan sample preparation from biological samples such as glycoproteins, mucins, etc.
During an acute-phase response, not only are concentrations of serum acute-phase glycoproteins altered, but their glycan structures are also dynamically modified by circulating glycosidases and glycosyltransferases (5, 6).
Protection of cattle from bovine herpesvirus type I (BHV-1) infection by immunization with individual viral glycoproteins. Virology 1987; 159: 57-66, doi: 10.1016/0042-6822(87)90347-3.
Work using gamma-irradiated HeV soluble G (HeVsG) glycoprotein produced in Chinese hamster ovary (CHO) cells was done under Australian Quarantine and Inspection Service in vivo permit number 2012/012, and work using non-gamma-irradiated HeVsG glycoprotein produced in 293F human embryonic kidney was done under Australian Quarantine and Inspection Service in vivo permit number 2010/027.
Thiel, "Processing of the envelope glycoproteins of pestiviruses," Journal of Virology, vol.