(Gangliosides are glycosphingolipids
that contribute a substantial presence to the outer leaflet of the cell plasma membrane.)
They also offer antibodies to glycosphingolipids
and inhibitors of enzymes involved in glycosphingolipid
Laboratory and clinical Pseudomonas aeruginosa strains do not bind glycosphingolipids
in vitro or during type IV pili-mediated initial host cell attachment.
Elucidation of the enigma of glycosphingolipids
in the regulation of inflammation and degeneration Great progress over the last 70 years Koichi FURUKAWA, Yuhsuke OHMI, Yuji KONDO, Robiul H.
In 1979, it rose as a human pathogen when it was first isolated from the pus specimen of a leg ulcer.2 Although the Lipopolysaccharide constituent of the outer wall of gram negative bacterium, which is highly capable of producing toxicity in host is completely absent in Sphingomonas paucimobilis, however, Glycosphingolipids
(GSL) are present in the outer layer which has structural similarities with Lipopolysaccharide and has proven to induce cytokines in the host.3 It was formerly known to cause opportunistic and nosocomial infections with low pathogenicity.4
Ophidiacerebrosides: Cytotoxic glycosphingolipids
containing a novel sphingosine from a sea star.
The investigators say the compound halts the production of certain fats called glycosphingolipids
, or GSLs, that are major components of skin and other cell membranes.
Scientists at the Neuroregeneration Research Institute at McLean Hospital had previously shown that there is an elevation of a class of lipids, called glycosphingolipids
, in the substantia nigra of patients with Parkinson's disease.
Generalized accumulation of neutral glycosphingolipids
with GM2 ganglioside accumulation in the brain.
De novo ceramide biosynthesis occurs at the cytosolic side of the endoplasmic reticulum (ER) and mitochondrion and serves as a precursor for the synthesis of more complex sphingolipids, including sphingomyelin and glycosphingolipids
, in the Golgi [38, 39].
Fabry disease (FD, OMIM #301500) is caused by the lysosomal accumulation of complex glycosphingolipids
, mainly globotriaosylceramide (Gb3) and its metabolites .
Scanu, "Distribution of glycosphingolipids
in the serum lipoproteins of normal human subjects and patients with hypo-and hyperlipidemias," Journal of Lipid Research, vol.