Apo C-2 indicates apolipoprotein C2; CM, chylomicron; GPIHBP1, glycosylphosphatidylinositol
anchored high-density lipoprotein binding protein 1; LMF-1, lipase maturation factor 1; LPL, lipoprotein lipase; VLDL, very low-density lipoprotein.
Induction of proinflammatory responses in macrophages by the glycosylphosphatidylinositols
of Plasmodium falciparum: cell signaling receptors, glycosylphosphatidylinositol
(GPI) structural requirement, and regulation of GPI activity.
Bertozzi, "The glycosylphosphatidylinositol
anchor: a complex membrane-anchoring structure for proteins," Biochemistry, vol.
It has been suggested that PIBF isoforms act as ligands implicated in the activation of proliferation signaling pathways including JAK1/STAT6 [9, 10, 12, 38], through the interaction with a receptor heterocomplex consisting of PIBF-R, which is attached to the plasma membrane by a glycosylphosphatidylinositol
, and membrane receptor IL-4R[alpha] [10,12].
All stereoisomers act as mediator of insulin action inside the cell : myoinositol (MYO) and D-chiro-inositol (DCI) are inositol-containing phosphoglycan (IPG) mediators, generated by hydrolysis of glycosylphosphatidylinositol
that inhibits cyclic AMP-dependent protein kinase (the first) and activates pyruvate dehydrogenase (the second one) .
The acquired mutation in PNH occurs in the phosphatidylinositol glycan anchor biosynthesis, class A (PIGA) gene, which is responsible for the first step in the synthesis of the glycosylphosphatidylinositol
(GPI) anchor that attaches a subset of proteins to the cell surface .
This molecule acts as mannose donor for N-glycosylation and glycosylphosphatidylinositol
Tatzelt, "Pathogenic mutations located in the hydrophobic core of the prion protein interfere with folding and attachment of the glycosylphosphatidylinositol
anchor," The Journal of Biological Chemistry, vol.
Westfall et al., "The first step of glycosylphosphatidylinositol
biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1," EMBO Journal, vol.
Rademacher, "The glycosylphosphatidylinositol
membrane anchor of Trypanosoma brucei variant surface glycoprotein," Biochemical Society Transactions, vol.
falciparum surface via glycosylphosphatidylinositol
anchor, validating its protective property .