of the GT43 Family (Nadine Anders and Paul Dupree)
COG complex-mediated recycling of Golgi glycosyltransferases
is essential for normal protein glycosylation.
A series of membrane bound glycosidases and glycosyltransferases
process the oligosaccharide as it moves through the endoplasmic reticulum (ER) and Golgi modifying it (Fig.
HBV transfection influences glycosylation through its effect on the activity of glycosyltransferases
, more specifically on GnT-III (24, 25).
For instance, increased integrin sialylation, mediated by the glycosyltransferase
ST6Gal I, leads to integrin activation, increased adhesion to ECM substrates, and augmented migration and invasion of colon cancer cell lines in vitro (52, 64).
Keywords in this release: Biotechnology, proteomics, functional glycomics, glycoproteins, glycosylation biopharmaceuticals, carbohydrate molecules, carbohydrate binding proteins, glycotherapeutic drug, Epogen, glycosyltransferases
, transgenic plants, transgenic animals, mammalian cells, microbial cell culture systems, industrial bioprocessing, microbioreactor, nanobiotechnology, carbon buckyballs, nanotubes, dendrimers, microarray, lab-on-a-chip, extremophiles.
A female patient with cystic fibrosis showed high %CDT as well as a type 2 Tf-IEF profile, supporting the hypothesis that altered function of cystic fibrosis transmembrane conductance regulator (CFTR) affects the compartmentalization of glycosyltransferases
in the Golgi, thereby disturbing protein glycosylation (39).
aureus in a model of human THP-1 macrophages C1-1471 Poster Arhin Mechanisms of Action of Oritavancin in Staphylococcus aureus C1-1472 Poster Belley Differential Targeting of Cell Wall Assembly Systems by Oritavancin C1-1473 Poster Rafai Far Cell-Wall Binding Sites of Desleucyl (fluorophenyl) benzylchloroeremomycin, a Damaged Oritavancin Analogue, in Staphylococcus aureus C1-1474 Poster Wang Probing the Mechanism of Inhibition of Bacterial Peptidoglycan Glycosyltransferases
by Glycopeptide Analogs Wed.
The GlycoAdvance Advisory Board comprises six leading scientists with expertise in glycoproteins and glycosyltransferases
In the third stage, specific glycosyltransferases
attach the sugars to a protein or to a glycan in the ER or Golgi.
The AFID Therapeutics' offerings are aimed at targets such as kinases, proteases, phosphatases, glycosidases, glycosyltransferases
, ribosomes, nucleic acids, monamine oxidases, adrenergic receptors and nucleic acids.
The patent specifically covers the enzymatic synthesis of oligosaccharides (complex carbohydrates) using specialized recombinant enzymes called glycosyltransferases