Goblet Cells


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Related to Goblet Cells: Paneth Cells, Crypts of Lieberkuhn

Goblet Cells

 

glandular epithelial cells in vertebrate animals and man that secrete mucus. Goblet cells are distributed individually in the mucous membranes of the intestine, air passages, efferent ducts of the pancreas and parotid glands, and the conjunctiva of the eyes. Goblet cells are formed from ordinary epithelial cells. The upper part of goblet cells, which is covered with microvilli, accumulates granules of secretion (mucinogen) that turn into a mass of mucus (mucin) when they absorb water. Goblet cells acquire the shape of a goblet (hence the name) when their apex swells and their base narrows. The upper part of the cells is then destroyed (apocrine secretion) and mucus is released into the lumen of the organ. The walls of the goblet cells collapse, become prismatic, and begin again to accumulate secretion.

N. V. NECHAEVA

References in periodicals archive ?
The intestine was short, with the intestinal epithelium presenting a simple type with a prismatic and cylindrical aspect and a large amount of goblet cells. These cells were strongly stained by PAS and AB, with neutral and acidic mucopolysaccharides, respectively.
There are three major epithelial cell types in the airways: ciliated cells, Clara cells, and goblet cells. Ciliated epithelium participates in the mucociliary clearance and expresses P -tubulin on the surface (Tompkins et al.
The ileum (harvested just proximal to the ileocecal junction) was processed, sectioned (3 [micro]m), and stained as previously described [28], and intestinal goblet cell hyperplasia was quantified as percent villi area covered by Periodic Acid-Schiff (PAS) stain as previously described [5].
Siggers et al., "Intestinal epithelial Toll-like receptor 4 regulates goblet cell development and is required for necrotizing enterocolitis in mice," Gastroenterology, vol.
The purpose of this study was to determine whether transgenic overexpression of adiponectin could affect allergic airways responses, including goblet cell hyperplasia.
A reduced number of goblet cells, often with reduced staining.
The mitochondria present in the microvilli of the goblet cell cavity would be related to active transport mechanisms of K+ ions, realised by these cells (Anderson and Harvey, 1966; Harvey et al., 1983; Moffett et al., 1995).
The natural disease (6) and the experimental infection (1) showed increased activity of goblet cells (GC) and infiltration of polymorphonuclear neutrophils (PMN) in the nasopharynx and nostrils.
(A) The model group with microvilli sloughing and mitochondria stretching, marked with 1 and 2 respectively; (B) Blank group with normal goblet cells and intestinal villi, marked with 3 and 4 respectively; (C) Positive drug group with microvilli shortening and membrane of goblet cells damaged, marked with 5 and 6 respectively; D and E were for CK group and TP group with integral microvilli, marked with 7 and 8, normal cell-cell junction and nuclear membrane, marked with 9 and 10, respectively.
Although no obvious gross pathologic changes were attributed to the nematode, histologic changes of bronchial epithelial hyperplasia and goblet cell metaplasia, consistent with chronic airway irritation were found in the lungs associated with Diplotriaena eggs.
Table V.- Effect of dietary MOS on villus height, crypt depth and goblet cells count of broiler birds during finisher phase.