carcinoid tumor of the appendix: report of five cases and review of the literature.
Most of the epithelia in the two areas were pseudostratified cylindrical ciliated epithelium with goblet cells
(respiratory epithelium), stratified cuboidal epithelium, and stratified squamous nonkeratinized epithelium.
Second, the more biopsy samples taken from the CLE, the more likely goblet cells
will be sampled.
17-19) A mucin stain may be used, in some cases, for the differential diagnosis with a goblet cell
carcinoid (see below).
Dual populations of cells were seen within the clusters: well-differentiated neuroendocrine cells with pale, eosinophilic, and granular cytoplasm, and mucin-containing goblet cells
(signet ring cell).
Mucinous BAC should be included in this category for the many issues previously discussed, together with adenocarcinomas that do not express surfactant proteins and other pneumocyte markers but show features of goblet cell
differentiation (in particular the expression of MUC5AC).
Intestinal-type goblet cells
were present in 56 cases, and the remaining 10 cases, although called Barrett on the original report, did not show either ITGCs or goblet cell
Serration is seen only in the upper half to third of the crypts, and it can be quite variable based on the degree of serration, content of cytoplasmic mucin, and the number of goblet cells
(Figure 3, B).
Etiologies and Mucin (MUC) Expression NSAID * Bile Reflux MUC Expression (n = 18) (n = 4) MUC1 Normal 6 0 Patchy loss 2 0 Complete loss 10 4 MUC5AC Normal 3 1 Aberrant ([dagger])-patchy 12 2 Aberrant ([dagger])-diffuse 3 1 MUC6 Normal 8 2 Aberrant ([double dagger])-focal 10 0 Aberrant ([double dagger])-diffuse 0 2 MUC2 Absent 17 3 Scattered in goblet cells
1 1 Scattered in columnar cells 0 0 Indeterminate MUC Expression (n = 14) P Value MUC1 Normal 6 Patchy loss 3 Complete loss 5 .
carcinoids were defined as tumors composed primarily of nests of mucin-filled goblet cells
surrounded by stroma.
There were more goblet cells
containing neutral and acidic mucins in the crop than in the stomach, perhaps suggesting that movement of digesta through the crop is greater than in the stomach region, as discussed earlier.
A villiform growth pattern is observed containing goblet cells
with mucous cells, Paneth cells and neuroendocrine cells.