Results on the screening of species of the lichen family Graphidaceae for superoxide-scavenging activity (SSA) and xanthine-oxidase inhibitory (IXO) activity have been presented.
Key words: Graphidaceae, inhibition of xanthine oxidase, Superoxide-scavenging activity, lichens, I[C.
Therefore, the aim of this study was to search for superoxide scavenging compounds and inhibitors of xanthine oxidase in 77 species of different genera Graphina, Graphis, Phaeographina, Phaeographis and Phaeographopsis in the lichen family Graphidaceae which is one of the most abundantly and widely occuring groups of lichens in India to develop new drugs for the prevention of free radical-mediated diseases and hyperuricemia related disorders.
Dried and identified herbarium specimens of the members (77 species) of the lichen family Graphidaceae collected from various parts of India and deposited in the Ajrekar Mycological Herbarium (AMH), Agharkar Research Institute, Pune, Maharashtra, India have been used for the superoxide scavenging activity and inhibition of xanthine oxidase assays (Table 1).
Seventy seven species of the family Graphidaceae were extracted with aqueous solution of methanol containing dimethyl sulphoxide.
26 [micro]g/ml for 50% inhibition of xanthine oxidase by the extract of selected species of the family Graphidaceae.