It may be given for a limited time as adjuvant therapy, when there is no gross disease
Radiotherapy 8 Gy in 1 fraction was administered using 6MV (mega voltage) Primus Linear Accelerator with 2-2.5 cm margin around the gross disease
at the Oncology department, CMH Rawalpindi.
The gross tumor volume (GTV) was defined as all gross disease
seen on the planning scans.
The patient was then treated with image-guided radiotherapy (IGRT) at the dose of 54 Gy in the surgical bed and in regions of gross disease
(bilateral paravertebral between T10 and S1).
(51) disease 3 patients 2013 who received postoperative RT Liu Gross disease
44% 10 months et al.
R2: gross disease
, macroscopic/visible tissue left behind.
For women who do not desire fertility, this includes total hysterectomy, bilateral salpingooophorectomy and removal of all gross disease
. Comprehensive nodal dissection is not indicated except when necessary for complete cytoreduction.
Since these studies were published between 1983 to 2012, the criteria for optimal cytoreduction varied from <2.5cm to no gross disease
, we tabulated them according to the criteria used to see the rate of optimal secondary cytoreduction and their OS [Table 5].
All but one patient (who was given adjuvant CRT after surgical resection) had gross disease
present at the start of treatment.
Postoperatively the patient did well and appears to be free of gross disease
after the surgical resection.
It was therefore concluded that a dose-response existed for subclinical and gross MCC, with doses of ?50Gy for subclinical disease, and greater than 55Gy for gross disease
to be considered.
"My own view, in terms of what we are now doing, which is treating gross disease
, is that gross disease
will become minimal disease - sub-clinical disease treated by new technologies."