growth factor

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Related to Growth factors: Cytokines

Growth factor

Any of a group of biologically active poly-peptides which function as hormonelike regulatory signals, controlling the growth and differentiation of responsive cells. Indeed, the distinction between growth factors and hormones is frequently arbitrary and stems more from the manner of their discovery than from a clear difference in function. See Cell differentiation, Hormone

The sequence of amino acids has been determined for several growth-factor polypeptides. This information permits a number of growth factors to be placed into families, members of which have related amino acid sequences, suggesting that they evolved from a single ancestral protein. The insulin family comprises somatemedins A and C, insulin, insulinlike growth factor (IGF), and multiplication-stimulating factor (MSF). A second family consists of sarcoma growth factor (SGF), transforming growth factors (TGFs), and epidermal growth factor (EGF). In addition, there are growth factors, such as nerve growth factor (NGF), fibroblast growth factor (FGF), and platelet-derived growth factor (PDGF), for which structural homologs have not been identified. See Insulin, Protein

The stimulation of cell proliferation by several growth factors is similar in some ways to the rapid cell proliferation characteristic of tumor cells. Furthermore, the growth factor receptors are similar to the tumor-causing proteins produced by several RNA tumor viruses. It has been demonstrated that platelet-derived growth factor is virtually identical to the tumor-causing protein of the RNA tumor virus, simian sarcoma virus. Some forms of cancer involve improper function of growth factors.

growth factor

[′grōth ‚fak·tər]
(aerospace engineering)
The additional weight of fuel and structural material required by the addition of 1 pound (0.45 kilogram) of payload to the original payload.
(physiology)
Any factor, genetic or extrinsic, which affects growth.
References in periodicals archive ?
Immunohistochemical localization of transforming growth factor [alpha] in the major salivary glands of male and female rats.
For this study, the researchers designed two -dimensional (2D) mineral nanoparticles to deliver growth factors for a prolonged duration to overcome this drawback.
He further added, "The sustained delivery of growth factors resulted in enhanced stem cell differentiation towards cartilage lineage and can be used for treatment of osteoarthritis."
Key growth factors within HSC660 include KGF, VEGF, and follistatin, which have been shown to be important in hair formation and the stimulation of resting hair follicles.
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The Index, created by Barclays Business Banking, reflects the strength of 12 key growth factors in total.
Effect of advanced age on the induction by androgen or thyroid hormone of epidermal growth factor and epidermal growth factor mRNA in the submandibular glands of C57BL/6 male mice.
In a study published in STEM CELLS Translational Medicine, they demonstrate how mesenchymal stem cells (MSCs) engineered to over-express basic fibroblast growth factor (bFGF) accelerated the healing of fractures in mice.
Younger skin can repair this damage thanks to unique proteins called growth factors.
The different speed of centrifugation produces a big fibrin matrix, with a high density and rich in growth factors as Rodella et al.
A growth factor molecule known as BMP-2 has been used in such treatments for several years to help encourage bone regrowth but large doses can cause harmful side-effects.
"The polymer facilitates a reaction with fibronectin, a protein which binds growth factors to allow the body to regenerate.