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see coenzymecoenzyme
, any one of a group of relatively small organic molecules required for the catalytic function of certain enzymes. A coenzyme may either be attached by covalent bonds to a particular enzyme or exist freely in solution, but in either case it participates intimately in
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γ-glutamyl cysteinyl glycine, a tripep-tide formed from radicals of three amino acids—glutamic acid, cysteine, and glycine. A peculiarity of the structure of glutathione is the peptide bond between cysteine and glutamic acid, in which the γ-carboxyl of the glutamic acid participates. Glutathione is present in all living organisms and is very important for oxidation-reduction reactions in connection with the capacity of the sulfhydryl group (SH—) of cysteine to undergo the reversible reaction

Glutathione can act as a coenzyme in the action of cathepsins, papain, and other proteolytic enzymes. The function of glutathione in metabolism apparently also includes the protection of the SH group of cytoplasm proteins against oxidation.


C10H17O6N3S A widely distributed tripeptide that is important in plant and animal tissue oxidation reactions.
References in periodicals archive ?
Moreover, the sample preparation and the extraction procedure developed allow high stability of Cys and GSH in the samples preventing their conversions.
Sustained oxidative challenge results in depletion of GSH and other antioxidants.
As indicated in Table 1, there were no significant differences between the 3 activity groups in terms of GSH concentration, systolic blood pressure (SBP), and diastolic blood pressure (DBP).
GSH content was assayed according to the procedure of Gronwald et al.
16Furthermore non-protein thiol such as GSH in conjugation with glutathione-S-transferase (GST) and glutathione peroxidase (GPx) plays a important role in defensive mechanism of cells against ROS.
There are several mechanisms through which As may influence concentrations of GSH and GSSG, including a) inducing the formation of ROS, which are then detoxified by GSH; b) consuming GSH during the reduction of AsV to Asm (Scott et al.
The association may be stronger than a simple correlation, since the production of pheomelanin consumes GSH.
GSH represents, all sizes of restaurants, as well as corporate and franchised restaurant chains nationwide, in addition to individual chefs, ranging from small local restaurants to James Beard Award winners.
MC) has announced that it has extended its contract with GSH, a provider of technology-driven energy and facilities management solutions.
The extraction of GSH in 4 ml of 100 mM phosphate Tempone, followed by deproteinization in acid sulfo-Sally-Silique 0.