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see coenzymecoenzyme
, any one of a group of relatively small organic molecules required for the catalytic function of certain enzymes. A coenzyme may either be attached by covalent bonds to a particular enzyme or exist freely in solution, but in either case it participates intimately in
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γ-glutamyl cysteinyl glycine, a tripep-tide formed from radicals of three amino acids—glutamic acid, cysteine, and glycine. A peculiarity of the structure of glutathione is the peptide bond between cysteine and glutamic acid, in which the γ-carboxyl of the glutamic acid participates. Glutathione is present in all living organisms and is very important for oxidation-reduction reactions in connection with the capacity of the sulfhydryl group (SH—) of cysteine to undergo the reversible reaction

Glutathione can act as a coenzyme in the action of cathepsins, papain, and other proteolytic enzymes. The function of glutathione in metabolism apparently also includes the protection of the SH group of cytoplasm proteins against oxidation.


C10H17O6N3S A widely distributed tripeptide that is important in plant and animal tissue oxidation reactions.
References in periodicals archive ?
Treatment with GSH supplementation, diagnosis of ASNHL, and months of follow-up were not found to significantly modify the rate of hearing loss.
These data collectively support that testes I-R injury causes oxidative response as evidenced by alterations in testes MPO, MDA and GSH levels.
In the present study, GSH concentration in blood was significantly reduced which is also indicative of oxidative stress.
This emphasizes an impact of glutathione and its redox ratio as good tools for the quantification of OxS and signalling the regulative role of GSH (Karelson et al.
In their discussion, the researchers also noted that, despite the fact that participants in the yoga group were older than those in the control group, and that their GSH levels prior to study commencement were lower than the control group, the yoga group had better antioxidant adaptation than the control group after six months of yoga training.
GSH was formed by incubation with dithiothreitol, conjugated with fluorescent monobromobimane (Calbiochem), and detected by HPLC (for the standardized procedure and further details, see the online Data Supplement).
Arkom said that specialist software and programming techniques have been used for the GSH website to enable market information, share prices, financial results and stock exchange announcements to be included.
GSH says the scheme will create 300 jobs and transform a club that currently offers an 18-link course.
Studies of these interactions helped explain why 3-FTyr GST exhibits spectral and kinetic properties distinct from the native GSH transferase.
The levels of plasma high-density lipoproteins, vitamin C, vitamin E and erythrocyte GSH [glutathione] were significantly lower.
The occurrence of GSH indicates that GSH related bicochemical pathways are operative in geckos.
Stevenson and Williams have safely treated hundreds of heart failure patients with implantable pacemakers, defibrillators, and loop recorders in the GSH Invasive Electrophysiology Laboratory.