Guanidine


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Related to Guanidine: guanidinium

guanidine

[′gwän·ə‚dēn]
(biochemistry)
CH5N2 Aminomethanamidine, a product of protein metabolism found in urine.

Guanidine

 

(also carbamidine). (H2N)2C=NH, colorless hygroscopic crystals; melting point, approximately 50° C. Guanidine absorbs C02 and moisture from the air and forms salts with acids. On hydrolysis it gives urea and ammonia.

Guanidine (or its salts) is obtained by reacting cyanamide with ammonia (or with ammonium salts).

H2N—C≡N + NH3→(H2N)2C═NH

H2N —C≡N +NH4Cl→(H2N)2C═NH.HCI

Guanidine is used to obtain medicinal and explosive substances and ion-exchange resins. A guanidine fragment enters into the composition of guanine (a component of nucleic acids), creatine, and arginine, the antibiotic streptomycin, and tetrodotoxin, a poison of animal origin.

References in periodicals archive ?
WiseGuyReports.com adds "Guanidine Market 2018 Global Analysis, Growth, Trends and Opportunities Research Report Forecasting to 2023" reports to its database
[ClickPress, Thu May 16 2019] Dicyandiamide is extremely reactive, odorless, white powder that is used as an intermediate for production of active pharmaceutical ingredients and a diverse range of guanidine salts.
Polyhexamethylene guanidine hydrochloride (PHMGH), Figure 1, was incorporated at 0.5 ([G.sub.0.5%]), 1 ([G.sub.1%]), and 2 ([G.sub.2%]) wt.% in the resin sealant for test groups and one group, without PHMGH, was used as control ([G.sub.CTRL]).
In vitro studies of the ultrastructural changes induced by guanidine in the nerves, muscle fibers and neuromuscular junction of the mouse diaphragm.
* Uremic toxins with similar chemical structures--ie Guanidines: small water soluble compounds that resemble urea and creatinine, also urea derivatives like ADMA.
The reported proton exchange rates for Glu (~5,500 [s.sup.-1], pH 7.0, 37[degrees]C, 7T [9], and amino protons) and Glc (~1,500 [s.sup.-1], pH 7.3, 37[degrees]C, 11.7 T [11], and hydroxyl protons) are substantially faster compared to those of Nic (~30 [s.sup.-1], rat brain, 4.7T [26], and amide protons) and Cre (~950 [s.sup.-1], pH 7.0, 37[degrees]C, 9.4 T [17], and guanidine protons).
For compounds (4d): A mixture of guanidine 0.23 gr (2.4 mmol), dibenzoylmethane 0.49 gr (2.2 mmol), arylaldehyde (2 mmol) and 0.67 gr NaHCO3 (8 mmol) were dissolved in DMF (20 mL).
The bacterial cells were disrupted with 6 M guanidine hydrochloride in the lysis buffer (pH 8.0) supplemented with 18 mM imidazole and 10 mM a-mercaptoethanol, followed by sonication of the cell lysate with 3 bursts of 30 sec each at 10 micron amplitude.
The researchers synthesized a simple compound known as guanidine designed to bind strongly to the contaminants and form insoluble crystals that are easily separated from water.
Four extraction methods were analyzed: phenol-chloroform with guanidine thiocyanate (Brazol[R], LabTrade, Brazil), silica-guanidine plus thiocyanate plus guanidine thiocyanate (QIAmp[R] DNA Mini Kit, Qiagen, USA), resin (Chelex[R] 100 resin, BioRad, USA), and resin precipitated with ethanol.
At the present work silica gel sequentially modified with polyhexamethylene guanidine and Tiron was suggested for sorption separation and sorption-photometric determination of Fe(III) and Fe(II).
In particular, the G8 (having eight guanidine groups) molecular carrier based on carbohydrate, such as sorbitol, was found to be very effective in delivering conjugated drugs to mouse brain [22-25].

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