The cGMP domain is the binding site for cyclic guanosine
mono-phosphate, and is therefore involved in the cyclic nucleotide mediated activation of the protein.
Epimedium brevicornum Maxim extract relaxes rabbit corpus cavernosum through multitargets on nitric oxide/cyclic guanosine
monophosphate signaling pathway.
GLMea and GLMaq fractions were the richest in terms of nucleobases containing thymine, uracil, adenine, and guanosine
. GLFph was the least endowed fraction containing lower quantities of cytosine and guanosine
tuberculosis: Mycobacterium tuberculosis AMs: Alveolar macrophages RRTB: Resistance to Rifampicin Tuberculosis MDR-TB: Multidrug-resistant TB SDG: Sustainable Development Goals XDR-TB: Extremely drug-resistant TB GTPases: Guanosine
triphosphatases G-proteins: GTP binding proteins PDB: Protein Data Bank NCBI: National Center for Biotechnology Information SAPS: SAP Application Performance Standard I-TASSER: Iterative Threading Assembly Refinement LOMETS: Local metathreading server RAMPAGE: Ramachandran Plot Analysis UniProt-GOA: Gene ontology annotation.
Four reference substances (guanosine
, adenosine, uracil, and adenine) were purchased from the National Institutes for Food and Drug Control (China), and uridine was purchased from the Nanchang Beta Biotechnology Co.
Nogueira, "Involvement of l-arginine-nitric oxide-cyclic guanosine
monophosphate pathway in the antidepressant-like effect of tramadol in the rat forced swimming test," Progress in Neuro-Psychopharmacology & Biological Psychiatry, vol.
The nucleosides including uridine, guanosine
, adenosine and cordycepin had been detected in the mycelial fermentation products of all the 6 strains.
NEP inhibitors have been developed that show enhanced diuretic and natriuretic actions through NPs and the second messenger cyclic guanosine
monophosphate (cGMP), particularly in the setting of experimental heart failure (HF), in which endogenous ANP and BNP are increased.
The T1 family (EC 184.108.40.206) ribonucleases (RNases) hydrolize RNA and cleave the 3',5'-phosphodiester bond between guanosine
3,-phosphate and the 5'-OH group of the adjacent nucleotide, forming a 2',3'-cyclic guanosine
phosphate in the first stage of a catalytic reaction.
Phosphodiesterases (PDEs) are critical components in the cyclic adenosine monophosphate/protein kinase A (cAMPPKA) and the cyclic guanosine
monophosphate/protein kinase G (cGMP-PKG) signaling pathways.
One such mechanism involves excessive production of nitric oxide (NO) and upregulation of cyclic guanosine
3',5'-monophosphate (cGMP) which results in dephosphorylation of myosin and subsequent vasodilation .
Gel formation of guanosine
5'-monophosphate (5'-GMP) under slightly acidic conditions (e.g., pH 5) was first discovered by Bang in 1910 .