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Blockade of H1 receptors prevents the histamine contribution to the symptoms of nasal itching, congestion, sneezing, rhinorrhea, and ocular irritation.
It revealed a higher affinity toward [H.sub.1] receptor compared to [H.sub.2] and [H.sub.3] histaminergic receptors and its selectivity toward H1 receptor was superior to other ocular antihistamines such as ketotifen, pheniramine, and levocabastine.
The H1 receptor antagonist chlorpheniramine (CPA) maleate salt and the H2 receptor antagonist ranitidine hydrochloride (RA; Sigma Chemical Co., USA) were prepared using saline as vehicle.
Keeping in view of the above ideas, the present study has been undertaken to evaluate the anti-inflammatory activity of newer non-sedative H1 receptor blocker cetirizine on the acute and chronic inflammatory models in albino rats.
Asenapine has high affinity for multiple dopamine, serotonin, noradrenergic [alpha]1 and [alpha]2, and histamine H1 receptors, where it works as an antagonist.
Although dosage and affinity for histamine H1 receptors play important roles in the sedative effect of a medication, what ultimately determines sedative effect is the combination of histamine H1 affinity and the amount of drug reaching the histamine H1 receptors in the CNS.
Art antipsychotic's potential for sedation is directly related to its affinity at Hi receptors and total drug concentration at the H1 receptor binding site.