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any of a large family of proteinsprotein,
any of the group of highly complex organic compounds found in all living cells and comprising the most abundant class of all biological molecules. Protein comprises approximately 50% of cellular dry weight.
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 of a spherical or globular shape that are widely distributed throughout the plant and animal kingdoms. Many of them have been prepared in pure crystalline form. The term globulin is a partly procedural one, used in classifying an otherwise diverse group of proteins that are soluble in water or dilute salt solutions. Among the most important are the immunoglobulins (Ig), the antibodies of the immune system (see immunityimmunity,
ability of an organism to resist disease by identifying and destroying foreign substances or organisms. Although all animals have some immune capabilities, little is known about nonmammalian immunity.
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). They are classified into five types based upon structure: IgA, IgD, IgE, IgG, and IgM. IgG or &ggr;-globulin is the most common and forms about 70% of the immunoglobins in the blood. Other globulins are involved in the transport of a variety of substances, including lipidslipids,
a broad class of organic products found in living systems. Most are insoluble in water but soluble in nonpolar solvents. The definition excludes the mineral oils and other petroleum products obtained from fossil material.
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, hormoneshormone,
secretory substance carried from one gland or organ of the body via the bloodstream to more or less specific tissues, where it exerts some influence upon the metabolism of the target tissue.
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, and inorganic ions.


A general name for any member of a heterogeneous group of serum proteins precipitated by 50% saturated ammonium sulfate. See Protein, Serum

The introduction of electrophoresis during the 1930s permitted subdivision of the globulins into alpha, beta, and gamma globulins on the basis of relative mobility at alkaline pH (8.6). However, each of these subgroups, though electrophoretically homogeneous, consists of a great variety of proteins with different biological properties and markedly different sizes and chemical properties other than net charge. Thus the α2-globulins, for example, as defined by moving boundary or paper electrophoresis, contain proteins ranging in molecular weight from approximately 50,000 to approximately 1,000,000 (α2-macroglobulin), each with differing functions. See Immunoglobulin


A heat-labile serum protein precipitated by 50% saturated ammonium sulfate and soluble in dilute salt solutions.


any of a group of simple proteins, including gamma globulin, that are generally insoluble in water but soluble in salt solutions and coagulated by heat
References in periodicals archive ?
Certain contacts of infected persons should receive HBIG and hepatitis B vaccine (see section on Postexposure Prophylaxis).
All infants of HBsAg-positive women received hepatitis B vaccine and all but one infant received HBIG.
Those who received HBIG maintained their anti-HBs titer [greater than or equal to]10 IU/L even one month after the 4th dose of vaccine.
Many studies have found an association between recording the maternal HBV status in delivery room records and the timely administration of HBIG.
HBIG (200 IU IM) and hepatitis B vaccine should be administered at different sites within 12 hours of delivery.
For infants born to HBV-infected women, administering ACIP-recommended postexposure prophylaxis of HBIG and HepB within hours of birth followed by completion of the HepB series has been shown to be 85%-95% effective in preventing HBV infection (2).
Mutant viruslarin tasiyici annelerde saptanmamasi, mutasyonun asi ve/veya HBIG gibi immunolojik baski sonucu olustugu dusunulmektedir.
Infants born to HBsAg-positive mothers should be given both hepatitis B vaccine and HBIG within 12 hours of birth, regardless of gestational age or birth weight.
Determine mother's HBsAg status as soon as possible and, if HBsAg-positive, administer HBIG (no later than age 1 week).
HBIG should be given to infants born to HBV+ mothers and to sexual contacts within 24 hours of exposure (Bader, 1996).