globulin

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globulin,

any of a large family of proteinsprotein,
any of the group of highly complex organic compounds found in all living cells and comprising the most abundant class of all biological molecules. Protein comprises approximately 50% of cellular dry weight.
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 of a spherical or globular shape that are widely distributed throughout the plant and animal kingdoms. Many of them have been prepared in pure crystalline form. The term globulin is a partly procedural one, used in classifying an otherwise diverse group of proteins that are soluble in water or dilute salt solutions. Among the most important are the immunoglobulins (Ig), the antibodies of the immune system (see immunityimmunity,
ability of an organism to resist disease by identifying and destroying foreign substances or organisms. Although all animals have some immune capabilities, little is known about nonmammalian immunity.
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). They are classified into five types based upon structure: IgA, IgD, IgE, IgG, and IgM. IgG or &ggr;-globulin is the most common and forms about 70% of the immunoglobins in the blood. Other globulins are involved in the transport of a variety of substances, including lipidslipids,
a broad class of organic products found in living systems. Most are insoluble in water but soluble in nonpolar solvents. The definition excludes the mineral oils and other petroleum products obtained from fossil material.
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, hormoneshormone,
secretory substance carried from one gland or organ of the body via the bloodstream to more or less specific tissues, where it exerts some influence upon the metabolism of the target tissue.
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, and inorganic ions.

Globulin

A general name for any member of a heterogeneous group of serum proteins precipitated by 50% saturated ammonium sulfate. See Protein, Serum

The introduction of electrophoresis during the 1930s permitted subdivision of the globulins into alpha, beta, and gamma globulins on the basis of relative mobility at alkaline pH (8.6). However, each of these subgroups, though electrophoretically homogeneous, consists of a great variety of proteins with different biological properties and markedly different sizes and chemical properties other than net charge. Thus the α2-globulins, for example, as defined by moving boundary or paper electrophoresis, contain proteins ranging in molecular weight from approximately 50,000 to approximately 1,000,000 (α2-macroglobulin), each with differing functions. See Immunoglobulin

globulin

[′gläb·yə·lən]
(biochemistry)
A heat-labile serum protein precipitated by 50% saturated ammonium sulfate and soluble in dilute salt solutions.

globulin

any of a group of simple proteins, including gamma globulin, that are generally insoluble in water but soluble in salt solutions and coagulated by heat
References in periodicals archive ?
Caption: Figure 4: Fetal: maternal concentration ratio for total human IgG (a) and IgG subclasses (b) following hepatitis B immune globulin (HBIG) administration at different gestation ages.
The first trial of long-term HBIG combined with the first-generation NA lamivudine (LAM) was conducted in 1998.
Pant Hospital in New Delhi, and colleagues randomized the newborns of 222 women who screened positive for HBsAg during their prenatal care to receive the 0.5-mL recombinant HBV vaccine at birth, 6 weeks, 10 weeks, and 14 weeks, either alone (116 infants) or with 0.5 mL intramuscular HBIG (106 infants).
Conclusion: Combined HBIG and vaccine may protect acute leukemia patients during the intensive chemotherapy period.
HBIg had been recommended only for babies born to 13 mothers whose serum contained HBeAg and to 6 mothers whose serum did not contain HBeAg or anti-HBe.
The post-exposure HBIG costs a minimum of $900 plus the $150 for the vaccine for exposed individuals not previously immune (Bukata, 1991).
Hepatitis B immune globulin, called HBIG, is also given.
However, if the mother tests positive for hepatitis B, the child must receive the first vaccine dose as well as hepatitis B immune globulin (HBIG) at or shortly after birth.
of universal maternal HBV screening, vaccination of all newborns, and the use of hepatitis B immune globulin (HBIG) for newborns of HBsAg-positive mothers.
Infants born to infected mothers may be given Hepatitis B immunoglobulin (HBIG) as an additional protection.
Hepatitis B vaccine provides long-term active immunity to HBV infection and HBIG provides short-term passive immunity to HBV infection until the infant responds to the vaccine (5).
A Chinese study assessed the long-term efficacy of postnatal active-passive vaccination (HBIG) in 8 733 high-school students.