antigen

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Related to HBcAg: anti-HBc, HBcAb, HBeAg, HBsAg

antigen:

see immunityimmunity,
ability of an organism to resist disease by identifying and destroying foreign substances or organisms. Although all animals have some immune capabilities, little is known about nonmammalian immunity.
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Antigen

A substance that initiates and mediates the formation of the corresponding immune body, termed antibody. Antigens can also react with formed antibodies. Antigen-antibody reactions serve as host defenses against microorganisms and other foreign bodies, or are used in laboratory tests for detecting the presence of either antigen or antibody. See Antibody, Antigen-antibody reaction

A protein immunogen (any substance capable of inducing an immune response) is usually composed of a large number of antigenic determinants. Thus, immunizing an animal with a protein results in the formation of a number of antibody molecules with different specificities. The antigenicity of a protein is determined by its sequence of amino acids as well as by its conformation. Antigens may be introduced into an animal by ingestion, inhalation, sometimes by contact with skin, or more regularly by injection into the bloodstream, skin, peritoneum, or other body part.

With a few exceptions, such as the autoantigens and the isoantigens of the blood groups, antigens produce antibody only in species other than the ones from which they are derived. All complete proteins are antigenic, as are many bacterial and other polysaccharides, some nucleic acids, and some lipids. Antigenicity may be modified or abolished by chemical treatments, including degradation or enzymatic digestion; it may be notably increased by the incorporation of antigen into oils or other adjuvants. See Isoantigen

Bacteria, viruses, protozoans, and other microorganisms are important sources of antigens. These may be proteins or polysaccharides derived from the outer surfaces of the cell (capsular antigens), from the cell interior (the somatic or O antigens), or from the flagella (the flagellar or H antigens). Other antigens either are excreted by the cell or are released into the medium during cell death and disruption; these include many enzymes and toxins, of which diphtheria, tetanus, and botulinus toxins are important examples. The presence of antibody to one of these constituent antigens in human or animal sera is presumptive evidence of past or present contact with specific microorganisms, and this finds application in clinical diagnosis and epidemiological surveys. See Botulism, Diphtheria, Toxin

Microbial antigens prepared to induce protective antibodies are termed vaccines. They may consist of either attenuated living or killed whole cells, or extracts of these. Since whole microorganisms are complex structures, vaccines may contain 10 or more distinct antigens, of which generally not more than one or two engender a protective antibody. Examples of these are smallpox vaccine, a living attenuated virus; typhoid vaccine, killed bacterial cells; and diphtheria toxoid, detoxified culture fluid. Several independent vaccines may be mixed to give a combined vaccine, and thus reduce the number of injections necessary for immunization, but such mixing can result in a lesser response to each component of the mixture. See Vaccination

Allergens are antigens that induce allergic states in humans or animals. Examples are preparations from poison ivy, cottonseed, or horse dander, or simple chemicals such as formaldehyde or picryl chloride. See Hypersensitivity, Immunology

McGraw-Hill Concise Encyclopedia of Bioscience. © 2002 by The McGraw-Hill Companies, Inc.

antigen

[′an·tə·jən]
(immunology)
A substance which reacts with the products of specific humoral or cellular immunity, even those induced by related heterologous immunogens.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.

antigen

a substance that stimulates the production of antibodies
Collins Discovery Encyclopedia, 1st edition © HarperCollins Publishers 2005
References in periodicals archive ?
Caption: FIGURE 1: Immunofluorescence and confocal images of hepatitis B virus core antigen (HBcAg) and hepatitis B virus x protein (HBx) and the stem cell marker epithelial cell adhesion molecule (EpCAM) in human hepatocellular carcinoma (HCC) and adjacent nontumor tissues.
HBcAg is found in liver tissue during acute or chronic infection.
Guide RNAs inhibited HBcAg expression in HepG2 cells, which showed that CRISPR/Cas9 mechanisms for efficient inactivation of viral genes targeting cccDNA may be possible.
The genome of HBV consists of the S gene, which codes for HBsAg; two pre-S region genes (pre-S1, pre-S2) that code for the hepatocyte receptor binding site; the C gene, which codes for HBcAg and HBeAg; the P gene, which codes for a DNA polymerase; and an X gene that activates viral and cellular promoters [4].
These genes are responsible for encoding the three envelope (or surface) proteins; small (S), medium (M), and large (L), that constitute the HBV surface antigen (HBsAg), the core protein (HBcAg), the nuclear protein (HBeAg), X protein (that can affect viral replication and proliferation, and interfere in cellular processes of apoptosis and carcinogenesis) and viral polymerase (P).
(6,8) There is non-significant excess of HBsAg with RAEB and anti HBcAg with AML.
Alkaline phosphatase 198 lU/I (normal 30-110 1U/l); serum bilirubin concentration was 4.4mg/dl, Anti HCV by ELISA, Hepatitis B surface antigen (HBsAg) and antibody (HBsAb), hepatitis B core antigen (HBcAg), and 1gM antibody were all absent; serological test results for recent Epstein-Barr virus and cytomegalovirus infections were negative.
Sera were screened for IgM antibody to HAV, IgM antibody to hepatitis B core antigen (HbcAg), hepatitis B surface antigen (HbsAg), and total Ig to HCV by using commercially available kits (HAVAB-EIA, Corzyme-M, AUZYME Monoclonal, and HCV EIA Third Generation; Abbott Laboratories, Abbott Park, IL).
The serological marker most widely used to detect exposure to HBV is HBcAg IgG; however, this marker is unable to define the status of the HBV carrier [2].
Studies on HBV mutations have shown that the precore variant results in the substitution of [G.sub.1896] by [A.sub.1896] in the core/ precore regions, leading to the loss of translation of HBeAg, but maintaining the production of HBcAg, where this mutation is known as [A.sub.1896].