testing is commonly used to screen for antibody-negative acute infection among blood donors; this method can detect HIV infection within 2 weeks of transmission.
Results were adjusted for factors such as race, sex, history of injection-drug use, use of various HAART medications, baseline CD4 and HIV RNA
levels, or history of antiretroviral therapy.
One interesting observation was that the HIV envelope of the rebounding plasma virus was genetically distinct from either cell-associated HIV RNA
or replication-competent virus in the latently infected CD4 T cells.
In a separate phase I/II investigation, the peptide fusion inhibitor T-1249 demonstrated potent short-term suppression of plasma HIV RNA
in 19 out of 24 patients who at baseline were failing a regimen containing enfuvirtide (ENF), or T-20, the precursor to T-1249.
results between 50 and 5,000 copies/mL should be regarded as indeterminate in the setting of suspected acute HIV infection with a negative antibody test, and should be repeated.
Genotyping in six patients whose HIV RNA
rebounded to more than 400 copies / mL while on Kaletra found no resistance to protease inhibitors; there was evidence of resistance to 3TC in three patients, consistent with previous studies.
Cell-associated (CA) HIV DNA and RNA were measured in peripheral blood mononuclear cells and in cell pellets from CSF, while cell-free HIV RNA
was quantified in CSF supernatant and blood plasma.
The treatment is successful if the patient maintained less than 50 copies/ml of HIV RNA
in their blood for at least 48 weeks.
ay HIV RNA
duzeyi; CD4+ T lenfositi sayisi; lokosit sayisi; lenfosit sayisi; hemoglobin degeri; trombosit sayisi; kreatinin, aspartat aminotransferaz (AST), alanin aminotransferaz (ALT), total kolesterol, dusuk yogunluklu ("low-density") lipoprotein (LDL), yuksek yogunluklu ("high-density") lipo-protein (HDL) ve trigliserid degerleri; son alti ay icinde doz atlama olup olmadigi, istenmeyen etkiler, HIV infeksiyonu-nun dogrulanma tarihi, ART'ye baslama tarihi, varsa tedavi degisikligi ve nedeni, yeni baslanan ART rejimi, mortalite ve nedeni, onceden olusturulmus hasta izlem formlarina kaydedildi.