human leukocyte antigen

(redirected from HLA antigen)
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human leukocyte antigen

[¦yü·mən ¦lü·kə‚sīt ′ant·i·jən]
(immunology)
Any of a group of antigens present on the surface of nucleated body cells that are coded for by the major histocompatibility complex of humans and thus allow the immune system to distinguish self and nonself. Abbreviated HLA.
References in periodicals archive ?
PRA represents the percent of the anti-HLA antibodies in recipient serum against a set panel of HLA antigens (6,7,8) and it can identify the risk of hyperacute or vascular rejection.
A1, Cw7, B8, DR3 HLA antigen combination associated with rapid decline of T-helper lymphocytes in HIV-1 infection.
Fearing GVHD, physicians generally refuse to attempt bone marrow transplants that involve more than a single HLA antigen mismatch.
The other advantage is, if you need a transplant and cannot find an exact HLA antigen match (say, instead of having all six HLA antigens match, you only have five, four, or three match), because cord blood has less immunological reactivity (which appears to be the case), you might be able to go to a two-antigen mismatch rather than a complete match and not have a lot of graft-versus-host disease.
The RainDance HLASeq Research Screening Panel utilizes next-generation sequencing technology to offer comprehensive coverage of the HLA super locus, including all Class I (HLA-A, -B, -C, -E, -F, -G, -K and -L) and Class II (HLA-DMA, -DOA, -DPA, -DQA, -DRA, -DMB, -DOB, -DPB1, -DQ1B1, -DQB2, as well as DRB1, -3, -4 and -5)genes, as well as several minor HLA antigen genes.
In the era of modern molecular pathology, patients can have their entire HLA antigen genome sequenced from a single swipe of buccal mucosa or an individual hair root.
The codogenic HLA antigen determines the reject reaction of organism, and is related to immune response and immunological regulation.
HLA antigen sensitization can cause kidney rejection and make patients incompatible with donors who share their tissue type.
At the time of transplantation, a virtual crossmatch is conducted to determine if the patients anti-HLA antibodies are directed against the donors specific HLA antigen if yes, they are called donor specific anti-HLA antibody (DSA).
About 30 percent of patients who might benefit from transplantation therapy are still unable to find a 0-1 HLA antigen disparate donor.
Solid organ transplantation requires that recipients are regularly screened for the presence of antibodies directed against the HLA antigen system.