HLA complex
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Related to HLA complex: HLA system, Human lymphocyte antigen
HLA complex
[¦āch¦el′ā ‚käm‚pleks] (immunology)
The major histocompatibility complex of humans.
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The HLA complex contains more than 220 genes, more than 40 of which encode leukocyte antigens.
(3,4) The breakthrough in unlocking this mystery came in 1958, when Jean Dausset discovered the human major histocompatibility complex (henceforth, referred to as the HLA complex), which shed much needed light on transplant biology.
The HLA complex has been reported to contribute to type 1 diabetes because HLA polymorphisms introduce genetic susceptibility to type 1 diabetes [28, 29].
The HLA complex, located on chromosome 6, comprises the most polymorphic genes in humans [1] and plays a pivotal role in matching for haematopoietic stem cell transplantation (HSCT).
The HLA complex allows the immune system to distinguish between self and non-self (foreign) entities.
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