This six-allele composition is referred to as a person's HLA type
The partners at Peptide Groove LLP developed HLA*IMP, or what they call the first HLA typing statistical imputation method which can call 4-digit HLA types
from SNP genotyping data with high accuracy.
For example, if one possible father's HLA type
is A3, A24; B49, B62, he is excluded for both the HLA-A and the HLA-B types.
An analysis of the HLA types
in our patients with AIH showed that HLA DR6 with its subtypes HLA-DRB1*13 and HLA-DRB1*14 were more prevalent in patients with AIH compared to controls.
However, the association between diet responsiveness and particular HLA types
suggests that autoimmune or allergic mechanisms are involved as well.
It can currently distinguish among 10,500 different alleles of all known HLA types
and can fully characterize new alleles yet to be discovered.
We tested people's HLA molecules, which determine tissue type, and found that certain HLA types
produce a strong T cell response that is associated with resistance to the disease, while other genetic variants are associated with a weaker T cell response, which led to poor protection," said Dr.
The results of phase II and long-term follow-up treatment of MS patients with dirucotide, published in 2006 in the European Journal of Neurology (EJN), showed that dirucotide delayed median time to disease progression for five years (versus placebo) in progressive MS patients with HLA types
DR2 and/or DR4, and generally well tolerated.
Because African-Americans have a greater variation of HLA types
, it is estimated that three times as many African-American donors are needed to equal a Caucasian's chance of obtaining a suitable match, according to the National Cord Blood program
Deletions in CCR5 coreceptors, as well as SDF variants and HLA types
, have been shown to protect against infection.