human leukocyte antigen

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human leukocyte antigen

[¦yü·mən ¦lü·kə‚sīt ′ant·i·jən]
(immunology)
Any of a group of antigens present on the surface of nucleated body cells that are coded for by the major histocompatibility complex of humans and thus allow the immune system to distinguish self and nonself. Abbreviated HLA.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
HLA type: individuals normally have two HLA-A alleles, two HLA-B alleles, and two HLA-DR alleles, one from each parent.
The partners at Peptide Groove LLP developed HLA*IMP, or what they call the first HLA typing statistical imputation method which can call 4-digit HLA types from SNP genotyping data with high accuracy.
Many of the questions that need to be answered in assignment of an HLA type for an individual can only be answered by molecular typing methods.
For example, if one possible father's HLA type is A3, A24; B49, B62, he is excluded for both the HLA-A and the HLA-B types.
X, A woman in another state whose HLA type had been determined for unrelated reasons, happened to be HLA compatible.
The data presented confirm the therapeutic potential of NPS for patients with early-stage TNBC in the adjuvant setting across HLA types A-02, -03, -24 and -26 which cover approximately 80-85% of the North American/European populations and 86-90% of Asian/Pacific basin populations.
An analysis of the HLA types in our patients with AIH showed that HLA DR6 with its subtypes HLA-DRB1*13 and HLA-DRB1*14 were more prevalent in patients with AIH compared to controls.
However, the association between diet responsiveness and particular HLA types suggests that autoimmune or allergic mechanisms are involved as well.
The sequence of dirucotide is associated with the autoimmune process in MS patients with certain immune response genes (HLA types DR2 and/or DR4); MS patients having these genes represent approximately 70 percent of all MS patients.
Because African-Americans have a greater variation of HLA types, it is estimated that three times as many African-American donors are needed to equal a Caucasian's chance of obtaining a suitable match, according to the National Cord Blood program
Deletions in CCR5 coreceptors, as well as SDF variants and HLA types, have been shown to protect against infection.
Likewise, your white blood cells have different surface markers, except that instead of three or four different choices, there are virtually hundreds of HLA types."