(2012) Setbp1 promotes the self-renewal of murine myeloid progenitors via activation of Hoxa9 and Hoxa10
. Blood 119, 6099-6108.
Fibroids affect gene expression pattern in the endometrium (such as HOXA10
), disrupting the window of implantation.
Analysis of fetal bone cells from the skull and vertebrae suggests that changes in the functioning of a gene, HoxA10
, may help explain this difference in early bone formation.
Decreased LPAR3 expression was correlated with the expression of other uterine receptivity biomarkers, such as osteopontin or HOXA10
, all regulated by progesterone (P4) .
In addition, human endometrium is dynamically regulated by the expression of HOXA10
gene that seems to be necessary for endometrial growth, differentiation and implantation (7).
Two weeks after birth, a period that corresponds to the peak of the differentiation process in mice, Hoxa9, Hoxa10
, Hoxa11, and Hoxa13 develop their characteristic spatial distribution throughout the Mullerian ducts: according to Taylor et al.
IL-2, T lymphocytes, CD3+, CD8+, CD4+, alpha V Beta 3 integrin, LIF, MMPs and HOXA10
have all been shown to be decreased in the endometrium from women with versus without hydrosalpinx (5-8) Though molecular inflammatory changes in the setting of hydrosalpinx are documented, a hysteroscopic endometrial phenotype in the presence of hydrosalpinx has not been well characterized.
Taylor has been studying the effect of the HOXA10
gene--which is required for an embryo to attach to the uterus--in mouse and primate models.
This gene, HOXA10
, orchestrates the activity of "hundreds--if not thousands --of downstream genes," Taylor says.
They found that BPA exposure during pregnancy had a lasting effect on one of the genes that is responsible for uterine development and subsequent fertility in both mice and humans (HOXA10
Effects of letrozole and clomiphene citrate on the expression of HOXA10
and integrin alpha v beta 3 in uterine epithelium of rats.