EURAMIC and HPFS do not support effect modification by PUFAs or selenium, respectively, whereas the KIHD study did find a statistically significant interaction term between MeHg exposure and PUFAs.
Three of the epidemiological studies--KIHD, HPFS, and NSHDS--provide risk estimates for total MI, including both fatal and nonfatal outcomes.
This study was restricted to NHS and HPFS participants living in metropolitan statistical areas (MSAs) in 13 U.
Comparisons between medical records and self-reported DM for subsamples of men from the HPFS cohort and women from the NHS resulted in confirmation of 97% and 98% of cases, respectively (Hu et al.
There were 3,784 incident cases of DM among 74,412 eligible participants in the NHS (448 per 100,000 person-years) and 688 cases among 15,048 eligible participants in the HPFS (402 per 100,000 person-years) (Table 1).
Descriptive characteristics of the NHS and HPFS participants at baseline, 1989.
11) HPFS (688 cases, 167,310 person-years) Age, season, year, state Fully adjusted (b) adjusted Single pollutant models [PM.
Tests of heterogeneity between the NHS and HPFS were not significant for any of the pooled meta-analysis models, but a multiplicative interaction term between sex and [PM.
Estimates from models that excluded participants with a baseline history of MI (leaving 3,672 NHS and 604 HPFS cases) or prior cancer (except nonmelanoma skin cancer) (leaving 3,311NHS and 522 HPFS cases) were similar to the reported estimates (data not shown).
Among men in the HPFS, associations were stronger with PM2.