Asymptomatic shedding tends to be more frequent and prolonged with primary genital HSV-2 infection
compared with HSV-1 infection.
For those with prevalent HSV-2, the adjusted RR of contracting HIV was 1.7 (95% confidence interval, 1.4-2.1), compared with 2.9 for those with incident HSV-2 infection
(95% CI, 1.7-5.0).
Mungmee, "Increase of genital HSV-1 and mixed HSV-1 and HSV-2 infection
in Bangkok, Thailand," Journal of the Medical Association of Thailand, vol.
A structured questionnaire was used to obtain information on socio-demographic variables such as age, education, occupation, type of family, geographic location, annual income, gestational weeks, and risk factors that may be associated with HSV-2 infection
, such as number of sex partners in previous one year.
Women are more susceptible to HSV-2 infection
than men (14).
 These results confirm the strong association of HSV-2 infection
Assuming homogeneous mixing of the population, the susceptible individuals acquire HSV-2 infection
at rate [lambda], with
Among women with pre-existing HSV-1 antibodies who demonstrate HSV-2 seroconversion between labor and 4-6 weeks after delivery, most will have acquired HSV-2 in the last trimester of pregnancy, as 68% of persons with prior HSV-1 infection demonstrate HSV-2 seroconversion within 3 months after HSV-2 infection
Interpretive phenomenology informed by Heidegger (Creswell, 2007; Laverty, 2003; Wojnar & Swanson, 2007) was used to explore the experiences of women living with HIV and symptomatic HSV-2 infection
. Interpretive phenomenology was an appropriate qualitative methodological framework as the goal was to explore and understand the meanings that women living with HIV ascribed to the phenomenon of interest, contextualizing these meaning in their culture, social location and temporal context (Creswell; Laverty; Wojnar & Swanson).
Because little is known about HSV-2 infection
rates and risks in teens with HIV and at risk for HIV, researchers at the University of Alabama at Birmingham conducted this analysis in the REACH study group.
In the multivariate analysis, HSV-2 infection
was associated with testing positive for HIV (adjusted odds ratios, 7.5 for women and 4.4 for men) and syphilis (3.5 and 2.4, respectively).
When the data were broken down by viral type, the vaccine showed 35% efficacy against HSV-1 infection but no efficacy against HSV-2 infection