In the light of the uncertainty in the influence of anaemia and haemoglobinopathies
on HbA1c, it is imperative that clinicians are aware of the caveats with HbA1c values when they make management decisions in the anaemic population.
For example, during a study by Rubenstein and others, (4) tests for haemoglobinopathies
and other genetic diseases were performed on the basis of family history and ethnic background.
and interfamily marriage in Pakistan.
Nasheed's letter on the Thalassaemia Prevention Bill said the bill states that the National Thalassaemia Centre (NTC) will be abolished after the establishment of Thalassaemia and Other Haemoglobinopathies
Centre, when the Act comes into effect.
Various diseases affecting turnover of red blood cells can give falsely elevated (iron deficiency anaemia, polycythaemia) or falsely decreased values (haemolytic anaemia, haemoglobinopathies
, malaria, blood loss, blood transfusion, HIV infection, use of antiretroviral drugs, renal impairment).
The laboratory diagnosis of thalassaemias and other haemoglobinopathies
can be achieved by a step-wise approach starting with a detailed clinical history, thorough haematologic evaluation [including haemoglobin level, complete blood count (CBC), reticulocyte count, and red blood cell (RBC) morphology], protein based analytic methods [alkaline and acid Hb-electrophoresis, isoelectric focusing (IEF) and high performance liquid chromatography (HPLC)] and nucleic acid based methods [such as polymerase chain reaction (PCR), reverse transcriptase (RT)-PCR, and sequencing of genomic DNA] (1,2).
Thus the present article shows the results of using inorganic erythrocytes in simulating of such hematological abnormalities as microspherocytosis, elliptocytosis, stomatocytosis, acanthocytosis and some haemoglobinopathies
Haemolytic anaemia is also a feature of haemoglobinopathies
, which are diagnosed by haemoglobin electrophoresis.
Those in that age span whose immune system is affected by medical treatment, who have haemoglobinopathies
, diabetes, or who are morbidly obese.
Contents include hypertensive disorders, cardiac conditions, thromboembolic disorders, anaemia's and haemoglobinopathies
, asthma, renal disorders, epilepsy and other neurological disorders, diabetes mellitus, thyroid disorders, eating disorders and disorders of the gastrointestinal system.
and a number of others.
Routine aspects of her antenatal care should not be overlooked such as screening for other conditions including infections (rubella, syphilis and hepatitis B), diabetes mellitus and genetic and chromosomal conditions such as haemoglobinopathies
and Down's syndrome.