Coyne JA (1985) The genetic basis of Haldane's rule. Nature 314: 736.
Laurie CC (1997) The weaker sex is heterogametic: 75 years of Haldane's rule. Genetics 147: 937-951.
Interspecific hybridizations between members of the melanogaster complex, with exception of one cross, follow the script of Haldane's rule. This complex includes four sibling species (D.
Furthermore, they suggest that Haldane's rule and its genetic basis may not be solely established in spermiogenesis but also in the premeiotic stages of spermatogenesis.
Haldane's rule, which explains why [F.sub.1] males are functionally sterile, has been invoked as a primary mechanism in mtDNA capture.
As we have shown that the backcrosses include fertile males, these data do not support Haldane's Rule as a simple explanation of mtDNA capture by the white-tailed deer.
Causes of sex-ratio bias may account for unisexual sterility in hybrids: a new explanation of Haldane's rule
and related phenomena.
In nearly all cases, pairs with two or fewer afflicted classes showed postzygotic isolation in male hybrids alone (as expected under Haldane's rule
), while those with three or more such classes necessarily included females.
Although Haldane's rule
applies to asymmetrical sterility or viability between homogametic and heterogametic hybrids in most diploid species, it is not directly relevant to species with other sex determination systems simply because they lack sex chromosomes and a heterogametic sex.
Where detailed genetic analysis has been possible, Haldane's rule
(sex-limited sterility) has been traced to disruptive transepistatic interactions among specific sites on sex chromosomes and autosomes (Coyne 1984; Orr 1987, 1989; Zouros et al.
This result is therefore again significant, and does not include the extra information that the ancestral state obeyed Haldane's rule
. This calculation involves the assumption that the probability of character switching is the same in all seven taxa.
One recently proposed evolutionary explanation posits that both Haldane's rule
and large sex-chromosome effects results from genes that cause meiotic drive (Frank, 1991a; Hurst and Pomiankowski, 1991).