Clinical and Endoscopic Features.--Syndromic hamartomatous
polyps may involve the entire GI tract; however, the duodenum is usually much less commonly involved.
lesions in bilateral hemisphere anterior periventricular deep white matter and left parietal deep white matter were observed via cranial MRI in our case.
The fact that no atypia was observed and the presence of benign endometrial glands and smooth muscle are in support of a hamartomatous
PJS is an autosomal dominant disease characterized by mucocutaneous pigmentation and hamartomatous
polyps of the gastrointestinal tract.
They sometimes carry different names such as lymphangioma, hamartomatous
tonsillar polyp, lymphangiomatous polyp, lymphangiectatic fibrous polyp, lymphangiectatic fibrolipomatous polyp, and so on according to their stromal components (2).
The mutation has already been reported in Cowden Syndrome (CS) that is another PTEN Hamartomatous
Tumor Syndrome, but to our knowledge, this variant has not been reported previously for association with BRRS.
Peutz-Jeghers syndrome (PJS), inherited as an autosomal dominant trait, is characterized by multiple gastrointestinal hamartomatous
polyps, mucocutaneous pigmentation, and an increased risk of neoplasm (1,2).
Lymphangioma is a benign hamartomatous
tumour that occurs because of congenital malformation of the lymphatic system and is characterized by benign proliferation of lymphatic vessels.
Non-neoplastic polyps include hyperplastic, hamartomatous
, inflammatory, and lymphoid polyps.
Neurofibromatosis is a hamartomatous
disorder of cellular components of neural crest origin.
It has been supposed that SANT represents an especial hamartomatous
transformation of splenic red pulp in response to an exaggerated nonneoplastic stromal proliferation.
CPFEs consist of a small, papillary, pedunculated, and avascular tumor covered by endothelium surrounded by a hyaline stroma , though some authors believe that CPFEs are hamartomatous
instead of neoplastic [5, 6].