Hand-Schüller-Christian disease

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Hand-Schüller-Christian disease

[¦hänt ¦shil·ər ′kris·chən di‚zēz]
(medicine)
A childhood syndrome characterized by exopthalmos, diabetes insipidus, and softened or punched-out areas in the bones.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
All these findings are consistent with Hand-schuller-Christian disease.
DISCUSSION: Histiocytosis X is a clonal proliferation disease of langerhan's cells that express an immunophenotype positive for S100 and CD1a (7) Hand-schuller-christian disease is a well described entity which has appeared sporadically till 1935.the cases have been reported from the western literature but authentic case reports from India are few (8,9).
[1] In 1868, Paul Langerhans discovered epidermal dendritic cells and the conditions which were characterized by these cells were subsequently called different names like Hand-Schuller-Christian disease, Letterer-Siwe disease, and eosinophilic granuloma.