Hantzsch synthesis

Hantzsch synthesis

[′hänsh ‚sin·thə·səs]
(organic chemistry)
The reaction whereby a pyrrole compound is formed when a β-ketoester, chloroacetone, and a primary amine condense.
References in periodicals archive ?
The acetylacetone (acac) method is based on the Hantzsch synthesis, where 2,4-pentanedione (acac), ammonium acetate, and formaldehyde are cyclized to form dihydropyridine 3,5-diacetyl-1,4-dihydrolutidine (DDL).
Classical 3-component Hantzsch synthesis of DHP compounds [54-57] is usually performed in solutions (including ionic liquids) by heating.
Ferrite magnetic nanoparticles with cysteine can be used as catalyst for the Hantzsch synthesis of hydroquinolines, 2.19.24, (Scheme 28) in a multicomponent reaction between 3,4 diphenoxy benzaldehyde, 2.19.22, ammonium acetate, 2.16.2, ethyl acetoacetate, 2.19.23, and 5,5-dimethylcyclohexane-1,3-dione, 2.19.18.
Thus, we decided to investigate the Hantzsch synthesis under these conditions.