Hartwell, Leland Harrison

Hartwell, Leland Harrison,

1939–, American cell biologist, b. Los Angeles, Ph.D. Massachusetts Institute of Technology, 1964. He is a professor at the Univ. of Washington (1968–) and since 1997 has also been president and director of the Fred Hutchinson Cancer Center in Seattle. Hartwell, along with Timothy R. HuntHunt, R. Timothy
(Richard Timothy Hunt), 1943–, British biochemist, Ph.D. Cambridge, 1968. Hunt was a researcher at the Albert Einstein College of Medicine, New York City (1968–81) and a professor at Cambridge (1981–90) before becoming (1991) principal
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 and Sir Paul M. NurseNurse, Sir Paul Maxime,
1949–, British biochemist, Ph.D. Univ. of East Anglia, 1973. Nurse was associated with the Imperial Cancer Research Fund (now Cancer Research UK London Research Institute) for two periods in his career (1984–88 and 1993–2003), becoming
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, was awarded the 2001 Nobel Prize in physiology or medicine for discoveries relating to key regulators of the cell cycle. Hartwell found a class of genes that controls the cell cycle, in particular he identifed a gene called start that plays a key role in initiating each cycle. The discoveries made by Hartwell and his fellow Nobel winners are important in understanding the development of chromosomal instabilities in cancer cells.
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