Hayflick limit

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Hayflick limit

[′hā‚flik ‚lim·ət]

(physiology)

The finite replicative capacity of normal somatic cells.

References in periodicals archive ?

The history of senescence starts with the discovery of the Hayflick limit in 1961.

THE ISOLATION OF HUMAN SENESCENT CELLS BY THEIR INABILITY TO ATTACH TO FIBRONECTIN

For the karyotyping process, the cells (subcultured at a 1:3 dilution, both early passages and after reaching the Hayflick limit) were subjected to a 4-hour demecolcemid (Sigma cat., no, D1925) incubation after 24 hours' cultivation followed by trypsin-ethylenediaminetetraacetic acid (EDTA) (Sigma, U.S.A.) detachment and lysis with hypotonic KCl (Sigma, U.S.A.) and fixation in acid/alcohol.

Growth kinetics, characterization, and plasticity of human menstrual blood stem cells

For example, one is to find a way to overcome the Hayflick limit on cell reproduction.

Life and death

While CSCs can duplicate for an indefinite amount of time, CCs are able to divide only a limited number of times (c.f., Hayflick limit; [23]).

A proposed quantitative index for assessing the potential contribution of reprogramming to cancer stem cell kinetics