Hayflick limit


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Hayflick limit

[′hā‚flik ‚lim·ət]
(physiology)
The finite replicative capacity of normal somatic cells.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
The history of senescence starts with the discovery of the Hayflick limit in 1961.
For the karyotyping process, the cells (subcultured at a 1:3 dilution, both early passages and after reaching the Hayflick limit) were subjected to a 4-hour demecolcemid (Sigma cat., no, D1925) incubation after 24 hours' cultivation followed by trypsin-ethylenediaminetetraacetic acid (EDTA) (Sigma, U.S.A.) detachment and lysis with hypotonic KCl (Sigma, U.S.A.) and fixation in acid/alcohol.
For example, one is to find a way to overcome the Hayflick limit on cell reproduction.
While CSCs can duplicate for an indefinite amount of time, CCs are able to divide only a limited number of times (c.f., Hayflick limit; [23]).