hemoglobin C

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hemoglobin C

[′hē·mə‚glō·bən ′sē]

(pathology)

A slow-moving abnormal hemoglobin associated with intraerythrocytic crystal formation, target cells, and chronic hemolytic anemia.

References in periodicals archive ?

First-generation assay epitopes typically span amino acids 4 to 10 of the Hb [beta] chain, (7) encompassing the altered amino acid at position 6 present in Hb S and Hb C variants.

Unintended Reporting of Misleading Hb [A.sub.1c] Values When Using Assays Incapable of Detecting Hemoglobin Variants

(5), (15) The ADA states that Hb [A.sub.1c] can be used to assess glycemic control in patients with Hb S trait; (16) other groups have expanded this recommendation to include Hb C and Hb D trait.

Impact of hemoglobin variants on Hb [A.sub.1c] interpretation: do we assume to much?

With alkaline agarose gel testing, some common Hb variants comigrate, such as Hb C, Hb E, Hb A2 & Hb O-Arab and Hb S, Hb D and Hb G.

Hemoglobinopathy and thalassemia detection: traditional methods and a novel method--capillary electrophoresis technology

The electrophoretic migration of Hb C, Hb E, Hb A2, and Hb O is similar at alkaline pH.

Hemoglobinopathies and clinical laboratory testing

Analysis by IEF showed the presence of Hb S and another Hb migrating near the position for Hb C. An HPLC analysis revealed the following: Hb A, <I% (RI, >94%); Hb [A.sub.2],3.5% (RI, 2.0%-3.8%); Hb F, 5.9% (RI, <2.0%); Hb S, 42.1% (RI, none); and Hb Other, 47.5% (RI, none).

A patient with a previous diagnosis of hemoglobin S/C disease with an unusually severe disease course

On the other hand, the following variants were not detectable with MS: Hb C, D, E, E-Saskatoon, O-Arab, Lepore-Boston -Washington, and Schlierbach.

Mass spectrometry: a tool for enhanced detection of hemoglobin variants

Whole blood samples from individuals homozygous for Hb A (n = 73) and heterozygous for Hb C or S (n = 46 and 76, respectively) were collected in EDTA-containing tubes.

Effects of hemoglobin C and S traits on glycohemoglobin measurements by eleven methods

As reported previously (23), Hb O-Arab and Hb C had statistically different retention times (P <0.001), whereas the %Hb values were not statistically different (P = 0.84).

HPLC retention time as a diagnostic tool for hemoglobin variants and hemoglobinopathies: a study of 60 000 samples in a clinical diagnostic laboratory

Whole blood samples from individuals homozygous for Hb A (n = 43) and heterozygous for Hb C or S (n = 43 and 61, respectively) were collected in EDTA tubes.

Effects of hemoglobin C and S traits on eight glycohemoglobin methods

One comparison (5) of CIEF with cation-exchange chromatography for the qualitative and quantitative analysis of Hb variants found that quantitative data between the two methods were highly correlated and that CIEF gave slightly better resolution of the unusual variants Hb C Harlem and Hb D Punjab.

Laboratory investigation of hemoglobinopathies and thalassemias: review and update

To eliminate suspected carryover when samples containing Hb C trait were analyzed by the A1c 2.2 Plus method, three samples homozygous for Hb A were analyzed but not reported after each sample containing Hb C trait.

Effects of hemoglobin C and S traits on seven glycohemoglobin methods

It previously has been shown that the presence of Hb C or S trait, both of which have substitutions at position six of the [beta] chain, can affect the accuracy of some immunoassay results (8).