hemoglobin S

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hemoglobin S

[′hē·mə‚glō·bən ′es]
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4) The most common variants in the United States in order of prevalence are Hb S, Hb C, Hb E, and Hb D, each the result of a single amino acid substitution in the Hb [beta] chain.
First-generation assay epitopes typically span amino acids 4 to 10 of the Hb [beta] chain, (7) encompassing the altered amino acid at position 6 present in Hb S and Hb C variants.
Heterozygous Hb S and Hb C variants have been shown to not interfere analytically with 3 of the 4 assays used here (Synchron System, Integra, and Trinity).
This analysis identified a substitution at codon 6 [GAG to GTG (Glu to Val)] on one allele, corresponding to Hb S, and a substitution at codon 1 [GTG to GCG (Val to Ala)] on the other allele, corresponding to Hb Raleigh.
In our case, the patient was heterozygous for Hb S, in which the N-terminal valine of the [beta] chain was glycated as Hb [S.
Hb S is characterized by a substitution at codon 6 (GAG to GTG) that leads to the replacement ofa glutamic acid residue in the [beta] chain by a valine residue.
In addition, there are other variants with electrophoretic mobilities identical or similar to those of Hb S and Hb C.
For specimens that showed chromatogram patterns consistent with sickle trait, the presence of Hb S was confirmed by use of the sodium metabisulfite reduction test (20).
No similar "right shoulder" was observed in the analysis of red cell hemolysates from trait carriers of Hb S ([[alpha].
1c] automated HPLC analyzers" coelute Hb E (and other common variants Hb S, Hb D, Hb C) with Hb A as one single Hb peak at the end of the chromatogram, making it impossible to detect the presence of Hb E in any Hb AE red cell hemolysates.
Accurate quantification of Hb S is an essential component in the discrimination of uncomplicated Hb S trait from other conditions characterized by the presence of Hb S.
Specimens from 319 patients identified as containing Hb S were used to evaluate the analytical performance of the Bio-Rad Variant and establish reference ranges.