hemoglobin S

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hemoglobin S

[′hē·mə‚glō·bən ′es]
References in periodicals archive ?
While the analytical interference of Hb S and Hb C has been well characterized for many Hb [A.
Hb S results from a substitution of valine for glutamic acid in the sixth position of the [beta]-chain of Hb A.
In our case, the patient was heterozygous for Hb S, in which the N-terminal valine of the [beta] chain was glycated as Hb [S.
SCD is diagnosed by the measurement of substantial amounts of Hb S by at least 2 separation methods, including HPLC and an electrophoretic method, such as IEF, cellulose acetate, or citrate agar.
For specimens that showed chromatogram patterns consistent with sickle trait, the presence of Hb S was confirmed by use of the sodium metabisulfite reduction test (20).
The package insert for the Cobas INTEGRA method indicates that specimens containing Hb S and Hb C variants may yield higher than expected gHb results.
Both Hb AC and Hb AS produced clinically significant interferences for the Diatrac and IMx methods, although the difference observed with Hb S with the IMx method was not statistically significant.
1C), but the results were higher than the Diamat results for samples with Hb S (Fig.
10), by assaying samples that contained [Hb AS (n = 8) and Hb SS (n = 7)] or did not contain Hb S [Hb AA (n = 57)] by all three methods.
2], Hb F, and abnormal Hbs such as Hb S and Hb C; these were clearly separated from the normal Hb.
1c] automated HPLC analyzers" coelute Hb E (and other common variants Hb S, Hb D, Hb C) with Hb A as one single Hb peak at the end of the chromatogram, making it impossible to detect the presence of Hb E in any Hb AE red cell hemolysates.
Specimens from 319 patients identified as containing Hb S were used to evaluate the analytical performance of the Bio-Rad Variant and establish reference ranges.