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Agglutination of red blood cells.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



the agglutination and subsequent precipitation of red blood cells, caused by hemagglutinins, bacteria, viruses, and agents capable of being adsorbed onto the surface of red blood cells.

Clusters of red blood cells, distinguishable to the naked eye as heaps, lumps, and clumps, are formed during hemagglutination. Hemagglutination is caused by the interaction of the agglutinogens present in red blood cells with plasma that contains agglutinins. Each agglutinogen has a corresponding agglutinin. The term “isohemagglutination” is used to designate the hemagglutination that takes place during the interaction of different blood groups in animals of the same species; “heterohemagglutination” is the term applied to the process in animals of different species. The laws of blood transfusion and identification of blood groups are based on the hemagglutination reaction. After the transfusion of incompatible blood, hemagglutination may occur in the bloodstream and cause severe (sometimes fatal) complications. In forensic medicine the hemagglutination reaction is used to determine the source of blood stains and as an additional test in cases of disputed paternity. In microbiology and immunology, the hemagglutination reaction is used to determine antiserum activity, for example, or type of virus. A distinction is made between active hemagglutination, which is caused by the direct action of an appropriate agent on the red blood cells, and passive hemagglutination, caused by a specific antiserum to the antigen previously adsorbed by the red blood cells. Hemagglutination may be caused by antibodies acting against one’s own red blood cells (auto-hemagglutination) or against red blood cells of the same species (homoagglutination) as well as by the polysaccharides of the causative bacteria of tuberculosis, plague, and tularemia, by the polysaccharides of the colon bacillus, and by the viruses of influenza, mumps, pneumonia of white mice, swine and horse influenza, smallpox vaccine, yellow fever, and other diseases.


The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
All serum samples were analysed quantitatively with known antigen H5 (control positive) obtained from Poultry Research Institute (PRI) Rawalpindi-Pakistan by Hemagglutination Inhibition (HI) test to check the prevalence of Avian Influenza (OIE, 2009; Allan et al., 1974).
pallidum hemagglutination T pallidum: Treponema pallidum UGH: University of Gondar Hospital VDRL: Venereal disease research laboratory.
Other recommendations include venereal disease research laboratory test with titer (38 of 462; 8.2%), fluorescent treponemal antibody-absorption test (35 of 462; 7.6%), an agglutination or hemagglutination assay (16 of 462; 3.5%), qualitative RPR (14 of 462; 3.0%), and rarely other assays.
Fractions with hemagglutination activity were collected and concentrated with Centricon filters (Millipore, Billerica, MA).
Keywords: Measles, Serodiagnosis, Indirect Hemagglutination Assay, Humoral Immune Response.
Carbohydrates for hemagglutination inhibition studies (D-glucose, D-fructose, D-galactose, lactose, N-acetyl-D-galactosamine, N-acetyl-D-glucosamine, xylose, D-raffinose, melibiose, L-arabinose, D-mannose and D-fucose) and size-exclusion standards were obtained from Sigma-Aldrich.
Indirect hemagglutination test was performed in six cases and was positive in 80% cases, suggesting a low sensitivity for hydatidosis for Casonis test compared to Indirect Hemagglutination test.
It was evaluated by measuring sensitivity of RBCs to LPAIV induced hemagglutination by using RBCs of two breeds and nine other avian species.
A clinical laboratory professional performing the required ABO recheck with anti-A, -B observed weak (w+) hemagglutination. She informed her supervisor, and the unit was immediately quarantined.
Immunization with this influenza nanoparticle vaccine elicited hemagglutination inhibition antibody titres more than tenfold higher than those from the licensed inactivated vaccine.
Leung and his associates at five medical centers measured hemagglutination inhibition antibody (HIA) titers at baseline and 28 days post vaccination in 223 subjects with AD (including a subset with Staphylococcus aureus colonization) and 135 nonatopic controls after administration per label of either a single dose of the seasonal 2012-2013 intradermal Fluzone or Fluzone for intramuscular injection.
The first immunoassay, a hemagglutination inhibition test, was described in a PhD thesis by Strausser in 1958, but it was never published in the peer-reviewed literature (4).

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