A global phylogenetic analysis in order to determine the host species and geography dependent features present in the evolution of avian H9N2 influenza hemagglutinin
Think of hemagglutinin
as a miniature broccoli stalk.
IAVchip DNA microarray was used to subtype simultaneously the tested IAV with probes specific to hemagglutinin
1-16 and neuraminidase 1-9 genes.
"This is why universal flu vaccine strategies in recent years have been focused more on the hemagglutinin
stem than on the head," noted Damian C.
One of the mutations Kawaoka found in the hemagglutinin
molecule may already be helping the virus adapt to humans.
(2009) Structures of receptor complexes formed by hemagglutinins
from the Asian Influenza pandemic of 1957.
Lectins and hemagglutinins
can be used as anti-HIV agents, anti-tumor agents and anti-fungal agents.
Prediction of mutations in H5N1 hemagglutinins
from influenza A virus.
The drop in pH alters the shape of the viral hemagglutinin
, thereby allowing the virus to fuse to the cell and open an entry for the virus' RNA to come in and start making fresh viruses.
(11.) Krammer F, Margine I, Tan GS, Pica N, Krause JC, Palese P A carboxy-terminal trimerization domain stabilizes conformational epitopes on the stalk domain of soluble recombinant hemagglutinin
Perhaps subtype H7N9 virus infection triggered a cross-reactive response between H7 and H3 or H1 hemagglutinins
. Primary infection with influenza virus can lead to a heterosubtypic hemagglutinin
antibody response (31).
of the influenza A(H3N2)v viruses differed substantially from the hemagglutinin
of the 2011-12 human seasonal vaccine virus, A/Perth/16/2011 (58-60 aa), which resulted from divergent evolutionary paths for the H3 hemagglutinin
in swine and human viruses.