A global phylogenetic analysis in order to determine the host species and geography dependent features present in the evolution of avian H9N2 influenza
hemagglutinin. PeerJ.
Think of
hemagglutinin as a miniature broccoli stalk.
IAVchip DNA microarray was used to subtype simultaneously the tested IAV with probes specific to
hemagglutinin 1-16 and neuraminidase 1-9 genes.
"This is why universal flu vaccine strategies in recent years have been focused more on the
hemagglutinin stem than on the head," noted Damian C.
One of the mutations Kawaoka found in the
hemagglutinin molecule may already be helping the virus adapt to humans.
(2009) Structures of receptor complexes formed by
hemagglutinins from the Asian Influenza pandemic of 1957.
Lectins and
hemagglutinins can be used as anti-HIV agents, anti-tumor agents and anti-fungal agents.
Prediction of mutations in H5N1
hemagglutinins from influenza A virus.
The drop in pH alters the shape of the viral
hemagglutinin, thereby allowing the virus to fuse to the cell and open an entry for the virus' RNA to come in and start making fresh viruses.
(11.) Krammer F, Margine I, Tan GS, Pica N, Krause JC, Palese P A carboxy-terminal trimerization domain stabilizes conformational epitopes on the stalk domain of soluble recombinant
hemagglutinin substrates.
Perhaps subtype H7N9 virus infection triggered a cross-reactive response between H7 and H3 or H1
hemagglutinins. Primary infection with influenza virus can lead to a heterosubtypic
hemagglutinin antibody response (31).
Hemagglutinins of the influenza A(H3N2)v viruses differed substantially from the
hemagglutinin of the 2011-12 human seasonal vaccine virus, A/Perth/16/2011 (58-60 aa), which resulted from divergent evolutionary paths for the H3
hemagglutinin in swine and human viruses.
