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Related to Heparin-induced thrombocytopenia: thrombin, disseminated intravascular coagulation


The condition of having an abnormally small number of platelets in the circulating blood.



a decrease in the number of platelets to fewer than 200,000 per mm3 in the peripheral blood. It may result from the redistribution of platelets in the bloodstream or from hemorrhage. Other causes are the intensified loss of platelets associated with thrombocytopenic purpura, splenomegaly, disseminated intravascular thrombosis, and the use of certain drugs. Thrombocytopenia may also result from disturbance of platelet formation in the bone marrow in leukemia or aplastic anemia, and from ionizing radiation. Blood clotting is impaired in thrombocytopenia, resulting in a tendency of the mucous membranes to bleed, as well as in hemorrhaging and the appearance of petechiae in the internal organs. Bleeding usually becomes continuous when the platelet count falls below 20,000–30,000 per mm3 of blood. Therapy involves treatment of the underlying disease, administration of hemostatics, and transfusion of platelets.

References in periodicals archive ?
Warfarin-induced skin necrosis and venous limb gangrene in the setting of heparin-induced thrombocytopenia.
Heparin-induced thrombocytopenia type II in subarachnoid hemorrhage patients: Incidence and complications.
Heparin-induced thrombocytopenia associated thrombosis in pediatric intensive care patients.
National survey of heparin-induced thrombocytopenia in the haemodialysis population of the UK population.
The relationship between the antiphospholipid syndrome and heparin-induced thrombocytopenia.
This patient had a classic case of heparin-induced thrombocytopenia with thromboses, which escaped diagnosis at three different medical facilities and under the care of numerous doctors.
The incidence of heparin-induced thrombocytopenia in hospitalized medical patients treated with subcutaneous unfractionated heparin: a prospective cohort study.
Risk for heparin-induced thrombocytopenia with unfractionated and low-molecular weight heparin thromboprophylaxis: a meta-analysis.
78/each to NHD * Half-life is approximately eight hours * Anti Xa levels * No neutralizing agent stable post * Cross-reactivity with heparin hemodialysis * Re-occurrence of HIT Note: NHD = Nocturnal hemodialysis HIT = Heparin-induced thrombocytopenia Table Six.
Heparin is critical intransplantation because it prevents blood clots from forming while the patient is on the heart-lung machine," explains Czer, who says the situation intensified when it was verified Vinson had heparin-induced thrombocytopenia (HIT) syndrome, which prohibited use of any heparin-related blood thinner.
The final chapter is dedicated to examination of the complication of heparin-induced thrombocytopenia.

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