heparin

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heparin

(hĕp`ərĭn), anticoagulantanticoagulant
, any of several substances that inhibit blood clot formation (see blood clotting). Some anticoagulants, such as the coumarin derivatives bishydroxycoumarin (Dicumarol) and warfarin (Coumadin) inhibit synthesis of prothrombin, a clot-forming substance, and other
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 produced by cells in many animals. A polysaccharide, heparin is found in the human body and occurs in greatest concentration in the tissues surrounding the capillaries of the lungs and the liver. The substance, extracted from animal tissues, is used clinically to delay blood clottingblood clotting,
process by which the blood coagulates to form solid masses, or clots. In minor injuries, small oval bodies called platelets, or thrombocytes, tend to collect and form plugs in blood vessel openings.
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heparin

[′hep·ə·rən]
(biochemistry)
An acid mucopolysaccharide acting as an antithrombin, antithromboplastin, and antiplatelet factor to prolong the clotting time of whole blood; occurs in a variety of tissues, most abundantly in liver.
References in periodicals archive ?
Superimposed coagulopathic conditions in cirrhosis: infection and endogenous heparinoids, renal failure, and endothelial dysfunction.
101] Other reports describe the use of plasmapheresis to remove immune complexes,[102] or high doses of immunoglobulin alone[103] or associated with LMWH and a heparinoid.
A hypocoagulation state may occur in severe systemic inflammatory response syndrome or in sepsis, which may be caused in part by endogenous heparinoids (1).
Delayed-type hypersensitivity skin reactions due to heparins and heparinoids.
If continued anticoagulation is required, alternative therapies are available such as low molecular weight heparin (LMWH), enoxaparin sodium/Lovenox[R], or the heparinoid, danaparoid sodium/Orgaran[R].
Heparinoid metabolism appears to significantly alter in pregnancy.
Treatment of superficial thrombophlebitis: a randomized, double-blind trial of heparinoid cream.
40) Results from randomized controlled trials involving unfractionated heparin, heparinoids, and low-molecular-weight heparin have not reported any benefit to these agents over aspirin at preventing early stroke recurrence.