Testing for HEV infection is recommended during initial assessments of posttransplant hepatic dysfunction
because histologic appearances in liver biopsy specimens may not clearly distinguish between graft rejection and acute viral hepatitis (Figure, panels A, B).
These reports further demonstrate that the excessive production of active oxygen species may be a causative factor in the advancing hepatic dysfunction
of BA patients with chronic diseases even after Kasai's portoenterostomy.
Because MEGX concentrations increase significantly with declining renal function, studies comparing healthy subjects with patients suffering from liver disease or patients with different degrees of hepatic dysfunction
should make use of study groups matched for glomerular filtration rate.
In some patients, the only signs of hepatic dysfunction
are minimal abnormalities in liver analytes.
In addition, no dosage adjustments were necessary based on age, gender, renal dysfunction, mild to moderate hepatic dysfunction
or concomitant use of digoxin or warfarin.
There is increased systemic exposure in patients with more severe hepatic dysfunction
Bronchospasm, dyspnoea, hepatic dysfunction
, acute pancreatitis, gastrointestinal discomfort, increased blood pressure, headache, vomiting, palpitations, nervousness, irritability, restlessness, mydriasis, closed angle glaucoma, tachycardia, dysuria, urinary retention.
Thus, in patients with hepatic dysfunction
, impaired lactate clearance contributes to elevated serum lactate levels (9,10).
Clinical features and complications of Alstrom syndrome Patient Presentation (*) Literature, % in the present study Retinal degeneration 98 + Sensorineural deafness 89 + Diabetes 82 + Obesity 98 - Acanthosis nigricans 68 + Hypergonadotropic 78 + hypogonadism Hypothyroidism 17 - Short stature 98 + Hepatic dysfunction
92 + Dilated cardiomyopathy 60 + Renal dysfunction 49 + *- 1.
Valproate products should not be given to patients with hepatic disease or significant hepatic dysfunction
because fatalities have occurred in patients on valproic acid and its derivatives.
The warning also notes that the product should not be used in women with renal or adrenal insufficiency, hepatic dysfunction
, or other conditions that predispose people to hyperkalemia.
Viral load in nasopharyngeal aspirates (n = 142) from day 10 to day 15 after onset of symptoms was associated with oxygen desaturatien, mechanical ventilation, diarrhea, hepatic dysfunction
, and death.