Hershko, Avram

Hershko, Avram,

1937–, Israeli biochemist, M.D. Hebrew Univ.–Hadassah Medical School, Jerusalem, 1965, Ph.D. 1969. Hershko has been a professor at the Rappaport Faculty of Medicine at the Technion (Israel Institute of Technology), Haifa, since 1972. In 2004 he received the Nobel Prize in Chemistry with Aaron CiechanoverCiechanover, Aaron,
1947–, Israeli biochemist, M.D. Hebrew Univ.–Hadassah Medical School, Jerusalem, 1974; D.Sc. Technion (Israel Institute of Technology), Haifa, 1982. He has been on the faculty at the Technion since 1986.
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 and Irwin RoseRose, Irwin,
1926–2015, American biochemist, b. Brooklyn, N.Y., Ph.D. Univ. of Chicago, 1952. Rose was on the faculty of Yale Medical School from 1954 to 1963 and a senior member of the Fox Chase Cancer Center in Philadelphia from 1963 until 1995.
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 for discovering the mechanism underlying protein degradation. Their work resulted in a molecular-level understanding of how cells control such processes as DNA repair, cell division, and immune functions by breaking down selected proteins using a regulatory tag called ubiquitin. This knowledge has helped in the fight against cystic fibrosis, cervical cancer, and other diseases that occur when the degradation process is flawed.
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