Syndromic causes of inner ear anomalies Syndrome Clinical features Gene involved Waardenburg Auditory-pigmentary syndrome PAX3, MITF, characterized by pigmentary SOX10, EDN3, abnormalities of the hair, SLUG including a white forelock and premature graying; pigmentary changes of the iris, such as heterochromia iridis
and brilliant blue eyes; and congenital sensorineural hearing loss.
"She is a white Maine Coon and she has heterochromia iridis
, which is a condition where a cat has different-colored eyes." Maine Coons are also one of the largest breeds of domestic cat.
can be a part of a congenital (present from birth) syndrome like the Waardenburg syndrome, Horner's syndrome, Sturge-Weber syndrome or Parry-Romberg syndrome, which are inherent.
The reduced pigmentation in the eyes was clearly evident from hazel green to light brown and bluish colouration of the iris but no symptom of heterochromia iridis
PPM may also be accompanied by persistent hyperplastic tunica vasculosa lentis, persistent hyperplastic primary vitreous, cataract, microphthalmia (BAYON et al., 2002; MITCHELL, 2011), retinal dysplasia (BAYON et al., 2002), iris hypoplasia (MISK et al., 1998; PINARD & BASRUR, 2011), heterochromia iridis
(MISK et al., 1998), angle-closure glaucoma caused by pupillary block, or peripheral anterior synechiae (YOUNG et al., 1974).