Functional cine imaging comparing wall motion at rest and under stress with dobutamine unmasks hibernating myocardium
at low doses.
The researchers cleverly circumvented the problem of having no human survivors to study by creating the hibernating myocardium
phenomenon in the first animal model--a pig--for the disease, and implanting a defibrillator similar to that used in patients with advanced heart disease.
Myocardial cell death and apoptosis in hibernating myocardium
The precise pathogenesis of stunned and hibernating myocardium
remains somewhat controversial and is beyond the scope of this article.
Coronary disease may result in repetitively stunned and/or hibernating myocardium
, both potentially reversible causes of heart failure.
The [beta]-blocker also might shift the energy substrate of the myocardium away from free fatty acids and toward glucose; that would further improve efficiency, especially in hibernating myocardium
, they said.
Bonow suggested that these patients may have a large amount of hibernating myocardium
that is salvaged by revascularization.