Caption: Figure 5: The expression of AVP-positive neurons in the hippocampal region
(immunohistochemistry, 200x): (a) normal control group, (b) sham-operation group, (c) sham-lesioned group, (d) PVN-lesioned group, and (e) VD model group.
Two-way analyses of variance (ANOVA) were utilized to examine the main effects of stress (nonstressed versus stressed) and honey treatment (placebo versus honey) on the memory performance, antioxidant enzymes activities, oxidative stress markers, stress hormone levels, and the number of Nissl-positive cells in the mPFC and hippocampal regions
. After confirming the normality of data and the homogeneity of variance of data, the significance of the differences between the means of the test and control studies was established by one-way analysis of variance (ANOVA) coupled with post hoc Tukey HSD test.
Group n Total number of pyramidal cells in CA1+CA2+CA3 hippocampal region
(cells/region) Mean SD Sham 16 231626 122134 Treatment 16 198299 79343 Control 16 161505 61173 Table IV Kruskal Wallis test result of the total pyramidal cells number (cells/hippocampus) of CA1+CA2+CA3 region of hippocampus.
Among our patients with Alzheimer's disease we did not detect APOE effects on cortical thickness; however, others have found regionally selective APOE-4 effects on the hippocampal region
Contribution of human hippocampal region
to novelty detection.
A recent study by Zucca and Valenzuela (2010) characterized the effect of ethanol on the release of trophic factors in the CA3 hippocampal region
. Stimulation of pyramidal-shaped neurons in this region causes the dendritic release of a protein known as brain-derived neurotrophic factor (BDNF), which induces a long-lasting enhancement (i.e., potentiation) of GABA transmission that is thought to be essential for the maturation of GABA inputs to these neurons (Gaiarsa 2004).
(33,34) In addition, many studies have reported that N-acetyl aspartate (an indirect means of inferring tissue damage) in the hippocampal region
of PTSD patients was decreased.
Asymmetry in the hippocampal region
specific for one of two closels related species of wild mice.
(1,2) Alzheimer's patients, clinically characterized by progressive cognition defects, have low levels of DHA in the brain compared with age-matched controls, and they also demonstrate low concentrations of neuroprotectins in the hippocampal region
. (3,4) Animal studies of transgenic models of Alzheimer's disease with amyloid deposition on neurons have demonstrated that DHA has preventive effects.
The difference could be because during the test, men used the left hippocampal region
of their brains, which is involved in navigation tasks.
The MRI shows abnormal high signal intensity in the right hippocampal region
. The FDG-PET shows a corresponding area of focal reduction of F-18 FDG uptake in the right hippocampal region
Nunomura and his colleagues evaluated postmortem tissue samples from the hippocampal region
of 16 subjects (aged 65-93 years at time of death) previously diagnosed with AD using Consortium to Establish a Registry for Alzheimer's Disease (CERAD) criteria.