Hippuric Acid

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Related to Hippurate: hippurate hydrolysis

hippuric acid

[hi′pyu̇r·ik ′as·əd]
(organic chemistry)
C6H5CONHCH2·COOH Colorless crystals melting at 188°C; soluble in hot water, alcohol, and ether; used in medicine and as a chemical intermediate.

Hippuric Acid


benzoylglycine, C6H5CONHCH2COOH, a compound consisting of benzoic acid and glycine groups; colorless, crystalline; melting point, 187.5° C.

Hippuric acid is formed in most animals and in man, primarily in the liver, and passes out in the urine. The biological significance of hippuric acid synthesis in the body is in the binding of benzoic acid, which is liberated during the destruction of the aromatic compounds that are a part of the makeup of plant tissues. In clinical practice the liver’s detoxication ability is measured by a test for hippuric acid synthesis (Quick’s test).

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Furthermore, the precursors of phenylacetylglycine (PAG) and hippurate are also produced by gut bacteria (Wei et al.
Prophylactic methenamine hippurate or nitrofurantoin in patients with an indwelling urinary catheter.
The main changes observed in the NMR spectra the first 4 days of hospitalization were complete suppression of hippurate excretion and decreased excretion of citrate, indicative of a renal tubular malfunction, and increased excretion of dimethylamine (DMA) and trimethylamine N-oxide (TMAO), which are considered as markers for papillary dysfunction (6, 7).
Campylobacter strains were presumptively identified with Gram stain, oxidase, and hippurate hydrolysis tests and confirmed with a C.
intestinal infection) is the abnormal excretion of D-lactate (not chromatographically separated from L-lactate), methylmalonate, p-hydroxyphenylacetate, p-hydroxyphenyllactate, phenylacetylglutamine, phenylpropionylglycine, glutarate, benzoate, and hippurate.
One isolate (M380) did not hydrolyze hippurate but produced acid from trehalose and xylose.
Highly significant differences were seen for citrate, alanine, lactate, and hippurate, which were all higher in diabetic children than in the unaffected individuals (Table 1).
Age dependence of renal function: clearance of iohexol and pamino hippurate in healthy males.
Isolates were determined to be Campylobacter by dark-field microscopic examination and hippurate hydrolysis (20-22).
The isolates were sent to Helsinki University Central Hospital (HUCH) Laboratory Diagnostics along with information about the patient (date of birth, sex, recent travel history) and the isolate (date of stool sampling, hippurate hydrolysis result).