Hippuric Acid


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hippuric acid

[hi′pyu̇r·ik ′as·əd]
(organic chemistry)
C6H5CONHCH2·COOH Colorless crystals melting at 188°C; soluble in hot water, alcohol, and ether; used in medicine and as a chemical intermediate.

Hippuric Acid

 

benzoylglycine, C6H5CONHCH2COOH, a compound consisting of benzoic acid and glycine groups; colorless, crystalline; melting point, 187.5° C.

Hippuric acid is formed in most animals and in man, primarily in the liver, and passes out in the urine. The biological significance of hippuric acid synthesis in the body is in the binding of benzoic acid, which is liberated during the destruction of the aromatic compounds that are a part of the makeup of plant tissues. In clinical practice the liver’s detoxication ability is measured by a test for hippuric acid synthesis (Quick’s test).

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Higaki, "Biomarker discovery for drug-induced phospholipidosis: phenylacetylglycine to hippuric acid ratio in urine and plasma as potential markers," Biomarkers, vol.
Under these experimental conditions, IS, p-cresyl sulfate (PCS), and phenyl sulfate (PhS) delayed growth rate (Figure 2(b)), whereas hippuric acid (HA) and IAA (Figure 2(c)) had no impact on growth rate.
Four additional uremic retention solutes, creatinine, hypoxanthine, indoxyl sulpate and hippuric acid, were identified from the HPLC profiles contributing to the UV absorbance.
Biological monitoring data routinely collected throughout the period of employment indicated that after the patient moved to the glue preparation department, he had a > 4-fold increase in urinary 2, 5-hexandione (a neuron-toxic metabolite of n-hexane) from 0.5-0.9 to 4.1 mg/L, accompanied by a > 1.5-fold increase in urinary hippuric acid (a toluene metabolite) from 360-700 to 1,040 mg/L (roughly corresponding to an increase from 0.26-0.5 to 0.74 g/g creatinine).
Urinary excretion of hippuric acid after administration of sodium benzoate.
As long ago as 1840, German doctors discovered that the urine of people who ate cranberries contained a chemical called hippuric acid. In their research, the doctors found that these same people had a significantly lower incidence of urinary tract infections (UTIs) such as cystitis and pyelonephritis.
Cranberries also contain hippuric acid, which has an antibacterial effect useful in fighting a variety of problems including tooth decay, ulcers and infections.
While it is possible that higher detoxication costs associated with excretion of other unmeasured conjugates such as hippuric acid and sulfates (Caldwell 1980, Sipes and Gandolfi 1991) by Great Basin woodrats caused greater mass loss, the few studies so far in mammals indicate energy costs of detoxication are relatively low (Guglielmo et al.
Or that it flooded the kidneys and bladder with large quantities of a natural antibiotic called hippuric acid. Neither turns out to be the case.
hippuric acid, will be applied at increasing rates to soil to determine their fate and effect on N cycling.
coli and several other urinary pathogens in vitro, (5) This effect may be due in part to hippuric acid, an antibacterial compound found in cranberry juice.